Synthesis of Pharmaceutically Relevant 2‐Aminotetralin and 3‐Aminochroman Derivatives via Enzymatic Reductive Amination-Reference-Cited by-同舟云学术

Synthesis of Pharmaceutically Relevant 2‐Aminotetralin and 3‐Aminochroman Derivatives via Enzymatic Reductive Amination

Published:2021-10-12 Issue:46 Volume:133 Page:24661-24665
ISSN:0044-8249
Container-title:Angewandte Chemie
language:en
Short-container-title:Angew. Chem.

Author:

Citoler Joan¹^ORCID,Harawa Vanessa¹^ORCID,Marshall James R.¹^ORCID,Bevinakatti Han²,Finnigan James D.³^ORCID,Charnock Simon J.³^ORCID,Turner Nicholas J.¹^ORCID

Affiliation:

1. Department of Chemistry University of Manchester Manchester Institute of Biotechnology 131 Princess Street Manchester M1 7DN UK

2. Nouryon (formerly AkzoNobel Specialty Chemicals) 10 Finderne Ave Bridgewater NJ 08807 USA

3. Prozomix Building 4, West End Ind. Estate Haltwhistle UK

Funder

H2020 European Research Council

Publisher

Wiley

Subject

General Medicine

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/ange.202110321

Reference46 articles.

1. Chiral Amine Synthesis

2. Novel 2-Aminotetralin and 3-AminoChroman Derivatives as Selective Serotonin 5-HT7 Receptor Agonists and Antagonists

3. Synthesis of novel 5-substituted-2-aminotetralin analogs: 5-HT1A and 5-HT7 G protein-coupled receptor affinity, 3D-QSAR and molecular modeling

4. A novel series of hybrid compounds derived by combining 2-aminotetralin and piperazine fragments: binding activity at D2 and D3 receptors

5. Synthesis and Biological Evaluation of Novel Compounds within a Class of 3-Aminochroman Derivatives with Dual 5-HT1A Receptor and Serotonin Transporter Affinity

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