Using Biological Photophysics to Map the Excited‐State Topology of Molecular Photosensitizers for Photodynamic Therapy

Author:

Chettri Avinash12,Yang Tingxiang12,Cole Houston D.3,Shi Ge3,Cameron Colin G.3,McFarland Sherri A.3,Dietzek‐Ivanšić Benjamin12ORCID

Affiliation:

1. Department Functional Interfaces Leibniz-Institute of Photonic Technology Jena Albert-Einstein-Straße 9 07745 Jena Germany

2. Institute of Physical Chemistry Friedrich-Schiller University Jena Helmholtzweg 4 07743 Jena Germany

3. Department of Chemistry and Biochemistry The University of Texas at Arlington Arlington TX-76019 USA

Abstract

AbstractThis study employs TLD1433, a RuII‐based photodynamic therapy (PDT) agent in human clinical trials, as a benchmark to establish protocols for studying the excited‐state dynamics of photosensitizers (PSs) in cellulo, in the local environment provided by human cancer cells. Very little is known about the excited‐state properties of any PS in live cells, and for TLD1433, it is terra incognita. This contribution targets a general problem in phototherapy, which is how to interrogate the light‐triggered, function‐determining processes of the PSs in the relevant biological environment, and establishes methodological advances to study the ultrafast photoinduced processes for TLD1433 when taken up by MCF7 cells. We generalize the methodological developments and results in terms of molecular physics by applying them to TLD1433’s analogue TLD1633, making this study a benchmark to investigate the excited‐state dynamics of phototoxic compounds in the complex biological environment.

Funder

Deutsche Forschungsgemeinschaft

European Commission

National Science Foundation

National Institutes of Health

Publisher

Wiley

Subject

General Medicine

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