pH‐Responsive Near‐Infrared Emitting Gold Nanoclusters

Author:

Zhou Shaochen12ORCID,Gustavsson Lotta12,Beaune Grégory12,Chandra Sourov12,Niskanen Jukka3,Ruokolainen Janne1,Timonen Jaakko V. I.12,Ikkala Olli12,Peng Bo12ORCID,Ras Robin H. A.12ORCID

Affiliation:

1. Department of Applied Physics School of Science Aalto University 00076 Espoo Finland

2. Center of Excellence in Life-Inspired Hybrid Materials LIBER Aalto University 00076 Espoo Finland

3. Department of Chemical Engineering and Metallurgy School of Chemical Engineering Aalto University 00076 Espoo Finland

Abstract

AbstractNear‐infrared (NIR) fluorophores with pH‐responsive properties suggest merits in biological analyses. This work establishes a general and effective method to obtain pH‐responsive NIR emissive gold nanoclusters by introducing aliphatic tertiary amine (TA) groups into the ligands. Computational study suggests that the pH‐responsive NIR emission is associated with electronic structure change upon protonation and deprotonation of TA groups. Photo‐induced electron transfer between deprotonated TA groups and the surface Au‐S motifs of gold nanoclusters can disrupt the radiative transitions and thereby decrease the photoluminescence intensity in basic environments (pH=7–11). By contrast, protonated TA groups curb the electron transfer and restore the photoluminescence intensity in acidic environments (pH=4–7). The pH‐responsive NIR‐emitting gold nanoclusters serve as a specific and sensitive probe for the lysosomes in the cells, offering non‐invasive emissions without interferences from intracellular autofluorescence.

Funder

Academy of Finland

European Research Council

Publisher

Wiley

Subject

General Medicine

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