Affiliation:
1. Department of Chemistry University of Zurich Winterthurerstrasse 190 CH 8057 Zurich Switzerland
Abstract
AbstractRadical‐mediated Hydrogen Atom Abstraction of Csp3−H bonds has become a powerful tool for the asymmetric functionalization of organic feedstocks. Here, we present an asymmetric synthesis of α‐aryl amides via carbamoylation of alkylarenes with isocyanates as electrophiles. The synergistic combination of a photoredox and a chiral nickel‐catalyst, enables the use of readily available and neutral reagents under mild reaction conditions and provides straightforward access to pharmacologically relevant motifs in enantiomerically pure form.
Funder
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
NCCR Catalysis