Dual Nickel/Photoredox‐Catalyzed Asymmetric Carbamoylation of Benzylic C(sp3)−H Bonds

Author:

Cuesta‐Galisteo Sergio1,Schörgenhumer Johannes1,Hervieu Cedric1,Nevado Cristina1ORCID

Affiliation:

1. Department of Chemistry University of Zurich Winterthurerstrasse 190 CH 8057 Zurich Switzerland

Abstract

AbstractRadical‐mediated Hydrogen Atom Abstraction of Csp3−H bonds has become a powerful tool for the asymmetric functionalization of organic feedstocks. Here, we present an asymmetric synthesis of α‐aryl amides via carbamoylation of alkylarenes with isocyanates as electrophiles. The synergistic combination of a photoredox and a chiral nickel‐catalyst, enables the use of readily available and neutral reagents under mild reaction conditions and provides straightforward access to pharmacologically relevant motifs in enantiomerically pure form.

Funder

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

NCCR Catalysis

Publisher

Wiley

Reference74 articles.

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