In situ Generated Iridium Nanoparticles as Hydride Donors in Photoredox‐Catalyzed Hydrogen Isotope Exchange Reactions with Deuterium and Tritium Gas

Author:

Kramp Henrik1,Weck Remo1,Sandvoss Martin1,Sib Anna1,Mencia Gabriel2,Fazzini Pier‐Francesco2,Chaudret Bruno2,Derdau Volker1ORCID

Affiliation:

1. Sanofi Germany, R&D Integrated Drug Discovery Industriepark Höchst 65926 Frankfurt am Main Germany

2. Laboratoire de Physique et Chimie des Nano-objets Institut National des Sciences Appliquées 135 avenue de Rangueil 31077 Toulouse Cedex 4 France

Abstract

AbstractWe have studied the photoredox‐catalyzed hydrogen isotope exchange (HIE) reaction with deuterium or tritium gas as isotope sources and in situ formed transition metal nanoparticles as hydrogen atom transfer pre‐catalysts. By this means we have found synergistic reactivities applying two different HIE mechanisms, namely photoredox‐catalyzed and CH‐functionalization HIE leading to the synthesis of highly deuterated complex molecules. Finally, we adopted these findings successfully to tritium chemistry.

Publisher

Wiley

Subject

General Medicine

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