Affiliation:
1. School of Science Faculty of Engineering and Science University of Greenwich Chatham Maritime Chatham Kent ME4 4TB UK
2. Department of Pharmacy University of Naples Federico II Via D. Montesano 49 80131 Napoli Italy
3. Department of Food and Drug University of Parma Parco area delle Scienze 27° Parma Italy
4. Discovery High-Throughput Chemistry Medicinal Chemistry GSK Medicines Research Centre Gunnels Wood Road Stevenage Hertfordshire SG1 2NY UK
Abstract
AbstractHydrogenation reactions are staple transformations commonly used across scientific fields to synthesise pharmaceuticals, natural products, and various functional materials. However, the vast majority of these reactions require the use of a toxic and costly catalyst leading to unpractical, hazardous and often functionally limited conditions. Herein, we report a new, general, practical, efficient, mild and high‐yielding hydrogen‐free electrochemical method for the reduction of alkene, alkyne, nitro and azido groups. Finally, this method has been applied to deuterium labelling.
Funder
HORIZON EUROPE European Innovation Council
Innovate UK
Leverhulme Trust