Separation of Mixtures of Rutin and Quercetin: Evaluating the Productivity of Preparative Chromatography-Reference-Cited by-同舟云学术

Separation of Mixtures of Rutin and Quercetin: Evaluating the Productivity of Preparative Chromatography

Published:2023-07-27 Issue:11 Volume:95 Page:1851-1857
ISSN:0009-286X
Container-title:Chemie Ingenieur Technik
language:en
Short-container-title:Chemie Ingenieur Technik

Author:

Vu Tien Dinh¹,Selvasembian Rangabhashiyam²³,Mutavdžin Ivana²⁴,Horosanskaia Elena²⁵,Lorenz Heike²,Seidel-Morgenstern Andreas²

Affiliation:

1. Hanoi University of Science and Technology School of Chemical Engineering No. 1 Dai Co Viet Hanoi Vietnam

2. Max-Planck-Institut für Dynamik komplexer technischer Systeme Sandtorstraße 1 39106 Magdeburg Germany

3. SRM University-AP Department of Environmental Science and Engineering 522240 Amaravati Andhra Pradesh India

4. CarboCode Germany GmbH Byk-Gulden-Straße 2 78467 Konstanz Germany

5. Salutas Pharma GmbH Analytical Science and Technology Department 39179 Barleben Germany

Abstract

AbstractThe flavonoid rutin is present in significant amounts in the flower buds of Sophora japonica L. It offers numerous desired pharmacological effects. Under certain extraction conditions quercetin is found as a hydrolysis product which needs to be separated from rutin. This paper describes the application of liquid chromatography to solve this task. Based on the determination of adsorption equilibrium constants and column efficiencies, the productivity of the separation process is estimated, and scale‐up considerations are presented. A comparison with alternatively directly crystallizing rutin from raw extracts is also reported.

Publisher

Wiley

Subject

Industrial and Manufacturing Engineering,General Chemical Engineering,General Chemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cite.202300050

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