Curcumin in the treatment of liver cancer: From mechanisms of action to nanoformulations

Author:

Shelash Al‐Hawary Sulieman Ibraheem1,Abdalkareem Jasim Saade2,M. Kadhim Mustafa34,Jaafar Saadoon Sarah5,Ahmad Irfan6ORCID,Romero Parra Rosario Mireya7,Hasan Hammoodi Suzan8,Abulkassim Roua9,M. Hameed Noora10,K. Alkhafaje Waleed11,Mustafa Yasser Fakri12ORCID,Javed Ansari Mohammad13

Affiliation:

1. Department of Business Administration, Business School Al al‐Bayt University Mafraq Jordan

2. Medical Laboratory Techniques Department Al‐maarif University College Al‐Anbar‐Ramadi Iraq

3. Medical Laboratory Techniques Department Al‐Farahidi University Baghdad Iraq

4. Medical Laboratory Techniques Department Al‐Turath University College Baghdad Iraq

5. College of Pharmacy Al‐Ayen University Nasiriyah Iraq

6. Department of Clinical Laboratory Sciences, College of Applied Medical Sciences King Khalid University Abha Saudi Arabia

7. Universidad Continental Lima Peru

8. Department of Dentistry Al‐Hadba University College Iraq

9. Al‐Manara College For Medical Sciences Misan Iraq

10. Anesthesia Techniques Al‐Nisour University College Baghdad Iraq

11. Anesthesia Techniques Department Al‐Mustaqbal University College Babylon Iraq

12. Department of Pharmaceutical Chemistry, College of Pharmacy University of Mosul Mosul Iraq

13. Department of Pharmaceutics, College of Pharmacy Prince Sattam Bin Abdulaziz University Al‐kharj Saudi Arabia

Abstract

AbstractLiver cancer is the sixth most prevalent cancer and ranks third in cancer‐related death, after lung and colorectal cancer. Various natural products have been discovered as alternatives to conventional cancer therapy strategies, including radiotherapy, chemotherapy, and surgery. Curcumin (CUR) with antiinflammatory, antioxidant, and antitumor activities has been associated with therapeutic benefits against various cancers. It can regulate multiple signaling pathways, such as PI3K/Akt, Wnt/β‐catenin, JAK/STAT, p53, MAPKs, and NF‐ĸB, which are involved in cancer cell proliferation, metastasis, apoptosis, angiogenesis, and autophagy. Due to its rapid metabolism, poor oral bioavailability, and low solubility in water, CUR application in clinical practices is restricted. To overcome these limitations, nanotechnology‐based delivery systems have been applied to use CUR nanoformulations with added benefits, such as reducing toxicity, improving cellular uptake, and targeting tumor sites. Besides the anticancer activities of CUR in combating various cancers, especially liver cancer, here we focused on the CUR nanoformulations, such as micelles, liposomes, polymeric, metal, and solid lipid nanoparticles, and others, in the treatment of liver cancer.

Publisher

Wiley

Subject

Pharmacology

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