Affiliation:
1. Department of Pathology Ditmanson Medical Foundation Chia‐Yi Christian Hospital Chiayi Taiwan
2. Department of Biotechnology and Bioindustry Sciences College of Bioscience and Biotechnology National Cheng Kung University Tainan Taiwan
3. Department of Cosmetic Science Chia Nan University of Pharmacy and Science Tainan Taiwan
4. PhD Program in Translational Medicine Rong Hsing Research Center for Translational Medicine National Chung Hsing University Taichung Taiwan
Abstract
AbstractFollicular lymphoma (FL) is a common subtype of non‐Hodgkin lymphoma derived from germinal center B‐cells. Small‐volume biopsies (SVBs), including fine‐needle aspiration, needle core biopsy, and cell blocks, are often used for the assessment of patients with FL. Recently, Fitzpatrick et al. found that additional biopsies were frequently needed to supplement SVB for the initial diagnosis of FL. However, regardless of the type of SVB used, additional biopsies were usually not necessary for assessments for transformed or recurrent FL. Their multi‐institutional study reflects the fact that SVB may be sufficient for clinical decision‐making in these medical settings, although surgical excision is the gold standard for a definitive diagnosis of FL. With ancillary tests and advances in molecular testing, SVB has become increasingly popular and helpful, although there are practical limitations.