Enhanced aggressiveness of benzopyrene-induced squamous carcinomas in transgenic mice overexpressing the proprotein convertase PACE4 (PCSK6)

Author:

Bassi Daniel E.12,Cenna Jonathan1,Zhang Jirong1,Cukierman Edna2,Klein-Szanto Andres J.12

Affiliation:

1. Department of Pathology; Fox Chase Cancer Center; Philadelphia Pennsylvania

2. Cancer Biology Program; Fox Chase Cancer Center; Philadelphia Pennsylvania

Funder

National Institutes of Health

Publisher

Wiley

Subject

Cancer Research,Molecular Biology

Reference53 articles.

1. The proprotein convertases;Steiner;Curr Opin Chem Biol,1998

2. Precursor convertases: An evolutionary ancient, cell-specific, combinatorial mechanism yielding diverse bioactive peptides and proteins;Seidah;Ann N Y Acad Sci,1998

3. Proprotein and prohormone convertases: A family of subtilases generating diverse bioactive polypeptides;Seidah;Brain Res,1999

4. The proprotein convertases furin and PACE4 play a significant role in tumor progression;Bassi;Mol Carcinog,2000

5. Human furin is a calcium-dependent serine endoprotease that recognizes the sequence Arg-X-X-Arg and efficiently cleaves anthrax toxin protective antigen;Molloy;J Biol Chem,1992

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