Link N is cleaved by human annulus fibrosus cells generating a fragment with retained biological activity-Reference-Cited by-同舟云学术

Link N is cleaved by human annulus fibrosus cells generating a fragment with retained biological activity

Published:2014-05-23 Issue:9 Volume:32 Page:1189-1197
ISSN:0736-0266
Container-title:Journal of Orthopaedic Research
language:en
Short-container-title:J. Orthop. Res.

Author:

Gawri Rahul¹²³⁴,Ouellet Jean³⁴,Önnerfjord Patrik⁵,Alkhatib Bashar¹³⁴,Steffen Thomas¹⁴,Heinegård Dick⁵,Roughley Peter⁴⁶,Antoniou John²⁴,Mwale Fackson²⁴,Haglund Lisbet¹³⁴

Affiliation:

1. Orthopaedic Research Laboratory; Royal Victoria Hospital; McGill University; Montréal Canada

2. Orthopaedic Research Laboratory; Lady Davis Institute for Medical Research, Jewish General Hospital; Montréal Canada

3. McGill Scoliosis and Spine Center; McGill University; Montréal Canada

4. Department of Surgery; McGill University; Montréal Canada

5. Department of Clinical Sciences; Section for Rheumatology; Molecular Skeletal Biology; Lund University; Lund Sweden

6. Shriners Hospital for Children; Montréal Canada

Funder

AO Spine and CIHR

Publisher

Wiley

Subject

Orthopedics and Sports Medicine

Reference39 articles.

1. Biology of intervertebral disc aging and degeneration: involvement of the extracellular matrix;Roughley;Spine,2004

2. The human lumbar intervertebral disc: evidence for changes in the biosynthesis and denaturation of the extracellular matrix with growth, maturation, ageing, and degeneration;Antoniou;J Clin Invest,1996

3. Senescence in human intervertebral discs;Roberts;Eur Spine J,2006

4. The role of interleukin-1 in the pathogenesis of human intervertebral disc degeneration;Le Maitre;Arthritis Res Ther,2005

5. Inflammatory mediators in intervertebral disk degeneration and discogenic pain;Wuertz;Global Spine J,2013

Cited by 9 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Chitosan-based hydrogels supplemented with gelatine and Link N enhance extracellular matrix deposition by encapsulated cells in a degenerative intervertebral disc environment;European Cells and Materials;2021-05-04

2. Link N suppresses interleukin-1β-induced biological effects on human osteoarthritic cartilage;European Cells and Materials;2020-01-15

3. Short link N acts as a disease modifying osteoarthritis drug;European Cells and Materials;2019-05-02

4. Exogenous Delivery of Link N mRNA into Chondrocytes and MSCs—The Potential Role in Increasing Anabolic Response;International Journal of Molecular Sciences;2019-04-06

5. Short Link N promotes disc repair in a rabbit model of disc degeneration;Arthritis Research & Therapy;2018-08-29