Deletion of Rptor in Preosteoblasts Reveals a Role for the Mammalian Target of Rapamycin Complex 1 ( mTORC1) Complex in Dietary‐Induced Changes to Bone Mass and Glucose Homeostasis in Female Mice

Author:

Tangseefa Pawanrat12ORCID,Martin Sally K.12,Arthur Agnieszka12,Panagopoulos Vasilios12,Page Amanda J.13,Wittert Gary A.134,Proud Christopher G.35,Fitter Stephen12,Zannettino Andrew C.W.126

Affiliation:

1. Adelaide Medical School, Faculty of Health and Medical Science University of Adelaide Adelaide South Australia Australia

2. Cancer Program, Precision Medicine Theme, South Australian Health and Medical Research Institute Adelaide South Australia Australia

3. Nutrition, Diabetes & Gut Health Program, Lifelong Health Theme, South Australian Health and Medical Research Institute Adelaide South Australia Australia

4. Freemasons Foundation Centre for Men's Health University of Adelaide Adelaide South Australia Australia

5. School of Biological Sciences, University of Adelaide Adelaide South Australia Australia

6. Central Adelaide Local Health Network Adelaide South Australia Australia

Funder

Australian Research Council

Publisher

Wiley

Subject

Orthopedics and Sports Medicine,Endocrinology, Diabetes and Metabolism

Reference97 articles.

1. Metabolic syndrome and insulin resistance: underlying causes and modification by exercise training;Roberts CK;Compr Physiol,2013

2. Obesity and the Metabolic Syndrome

3. Molecular mechanisms of mTOR‐mediated translational control;Ma XM;Cell Mol Biol,2009

4. S6K Directly Phosphorylates IRS-1 on Ser-270 to Promote Insulin Resistance in Response to TNF-α Signaling through IKK2

5. Turnover of the Active Fraction of IRS1 Involves Raptor-mTOR- and S6K1-Dependent Serine Phosphorylation in Cell Culture Models of Tuberous Sclerosis

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