Cinnamophilin Isolated from Cinnamomum philippinense Protects against Collagen Degradation in Human Chondrocytes

Author:

Lu Yung-Chang123,Hsiao George4,Lin Kuan-Hung4,Hsieh Ming-Shium15,Jayakumar Thanasekaran4,Wu Tian-Shung1678,Sheu Joen-Rong14

Affiliation:

1. Graduate Institute of Clinical Medicine, College of Medicine; Taipei Medical University; Taipei Taiwan

2. Department of Orthopedic Surgery; Mackay Memorial Hospital; Taipei

3. Department of Leisure Sports and Health Management, College of Humanities and Sciences; St. John's University; Tamsui Taipei Taiwan

4. Graduate Institute of Medical Sciences and Department of Pharmacology, College of Medicine; Taipei Medical University; Taipei Taiwan

5. Department of Orthopedic Surgery; En Chu Kong Hospital; Sanshia Taipei Taiwan

6. School of Pharmacy; China Medical University; Taichung Taiwan

7. Department of Chemistry; National Cheng Kung University; Tainan Taiwan

8. Chinese Medicine Research and Development Center; China Medical University Hospital; Taichung Taiwan

Publisher

Wiley

Subject

Pharmacology

Reference47 articles.

1. Green tea polyphenol epigallocatechin-3-gallate (EGCG) differentially inhibits interleukin-1 beta-induced expression of matrix metalloproteinase-1 and −13 in human chondrocytes;Ahmed;J Pharmacol Exp Ther,2004

2. Gene expression profiling of serum- and interleukin-1 beta-stimulated primary human adult articular chondrocytes--a molecular analysis based on chondrocytes isolated from one donor;Aigner;Cytokine,2005

3. Signaling transduction: target in osteoarthritis;Berenbaum;Curr Opin Rheumatol,2004

4. Effective adenoviral transfer of IkappaBalpha into human fibroblasts and chondrosarcoma cells reveals that the induction of matrix metalloproteinases and proinflammatory cytokines is nuclear factor-kappaB dependent;Bondeson;J Rheumatol,2000

5. Matrix metalloproteinases: a tail of a frog that became a prince;Brinckerhoff;Nat Rev Mol Cell Biol,2002

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