Multiple mechanisms of Rottlerin toxicity in A375 melanoma cells

Author:

Ietta Francesca1,Valacchi Giuseppe234,Benincasa Linda1,Pecorelli Alessandra3,Cresti Laura1,Maioli Emanuela1ORCID

Affiliation:

1. Department of Life SciencesUniversity of Siena Siena Italy

2. Department of Biomedical and Specialist Surgical SciencesUniversity of Ferrara Ferrara Italy

3. NC State University, Plants for Human Health Institute Kannapolis North Carolina

4. Department of Food and NutritionKyung Hee University Seoul South Korea

Funder

Università degli Studi di Siena

Publisher

Wiley

Subject

Clinical Biochemistry,Molecular Medicine,General Medicine,Biochemistry

Reference38 articles.

1. Rottlerin and Cancer: Novel Evidence and Mechanisms

2. Tumor suppressive role of rottlerin in cancer therapy;Ma J;Am J Transl Res,2018

3. Rottlerin is a mitochondrial uncoupler that decreases cellular ATP levels and indirectly blocks protein kinase Cdelta tyrosine phosphorylation;Soltoff SP;J Biol Chem,2001

4. Rottlerin Inhibits ROS Formation and Prevents NFκB Activation in MCF-7 and HT-29 Cells

5. Rottlerin inhibits the nuclear factor κB/Cyclin-D1 cascade in MCF-7 breast cancer cells

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