Fine-scale mapping of 8q24 locus identifies multiple independent risk variants for breast cancer

Author:

Shi Jiajun1,Zhang Yanfeng1,Zheng Wei1,Michailidou Kyriaki2,Ghoussaini Maya3,Bolla Manjeet K.2,Wang Qin2,Dennis Joe3,Lush Michael3,Milne Roger L.45,Shu Xiao-Ou1,Beesley Jonathan6,Kar Siddhartha3,Andrulis Irene L.78,Anton-Culver Hoda9,Arndt Volker10,Beckmann Matthias W.11,Zhao Zhiguo1,Guo Xingyi1,Benitez Javier1213,Beeghly-Fadiel Alicia1,Blot William114,Bogdanova Natalia V.15,Bojesen Stig E.161718,Brauch Hiltrud192021,Brenner Hermann102122,Brinton Louise23,Broeks Annegien24,Brüning Thomas25,Burwinkel Barbara2627,Cai Hui1,Canisius Sander28,Chang-Claude Jenny29,Choi Ji-Yeob3031,Couch Fergus J.32,Cox Angela33,Cross Simon S.34,Czene Kamila35,Darabi Hatef35,Devilee Peter3637,Droit Arnaud38,Dork Thilo39,Fasching Peter A.1140,Fletcher Olivia41,Flyger Henrik42,Fostira Florentia43,Gaborieau Valerie44,García-Closas Montserrat4145,Giles Graham G.45,Grip Mervi46,Guenel Pascal4748,Haiman Christopher A.49,Hamann Ute50,Hartman Mikael5152,Miao Hui51,Hollestelle Antoinette53,Hopper John L.54,Hsiung Chia-Ni55,Ito Hidemi56,Jakubowska Anna57,Johnson Nichola41,Torres Diana5058,Kabisch Maria50,Kang Daehee303159,Khan Sofia60,Knight Julia A.6162,Kosma Veli-Matti6364,Lambrechts Diether6566,Li Jingmei35,Lindblom Annika67,Lophatananon Artitaya68,Lubinski Jan57,Mannermaa Arto6364,Manoukian Siranoush69,Le Marchand Loic70,Margolin Sara71,Marme Frederik7273,Matsuo Keitaro74,McLean Catriona75,Meindl Alfons54,Muir Kenneth6876,Neuhausen Susan L.77,Nevanlinna Heli60,Nord Silje7879,Børresen-Dale Anne-Lise7879,Olson Janet E.80,Orr Nick81,van den Ouweland Ans M.W.82,Peterlongo Paolo83,Choudary Putti Thomas84,Rudolph Anja29,Sangrajrang Suleeporn85,Sawyer Elinor J.86,Schmidt Marjanka K.24,Schmutzler Rita K.87888990,Shen Chen-Yang9192,Hou Ming-Feng93,Shrubsole Matha J.1,Southey Melissa C.94,Swerdlow Anthony95,Hwang Teo Soo9697,Thienpont Bernard6566,Toland Amanda E.98,Tollenaar Robert A.E.M.99,Tomlinson Ian100,Truong Therese4748,Tseng Chiu-chen49,Wen Wanqing1,Winqvist Robert101102,Wu Anna H.49,Har Yip Cheng97,Zamora Pilar M.103,Zheng Ying104,Floris Giuseppe105,Cheng Ching-Yu106,Hooning Maartje J.53,Martens John W.M.53,Seynaeve Caroline53,Kristensen Vessela N.7879107,Hall Per35,Pharoah Paul D.P.23,Simard Jacques38,Chenevix-Trench Georgia6108,Dunning Alison M.3,Antoniou Antonis C.2,Easton Douglas F.23,Cai Qiuyin1,Long Jirong1,

Affiliation:

1. Division of Epidemiology; Department of Medicine; Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine; Nashville TN

2. Centre for Cancer Genetic Epidemiology; Department of Public Health and Primary Care; University of Cambridge; Cambridge United Kingdom

3. Centre for Cancer Genetic Epidemiology; Department of Oncology; University of Cambridge; Cambridge United Kingdom

4. The Cancer Council Victoria; Cancer Epidemiology Centre; Melbourne Vic Australia

5. Centre for Epidemiology and Biostatistics; School of Population and Global Health; The University of Melbourne; Melbourne Vic Australia

6. Department of Genetics; QIMR Berghofer Medical Research Institute; Brisbane Qld Australia

7. Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Toronto ON Canada

8. Department of Molecular Genetics; University of Toronto; Toronto ON Canada

9. Department of Epidemiology; University of California Irvine; Irvine CA

10. Division of Clinical Epidemiology and Aging Research; German Cancer Research Center; Heidelberg Germany

11. Department of Gynaecology and Obstetrics; University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg; Erlangen Germany

12. Human Cancer Genetics Program; Spanish National Cancer Research Centre; Madrid Spain

13. Centro De Investigación En Red De Enfermedades Raras; Valencia Spain

14. International Epidemiology Institute; Rockville MD

15. Department of Radiation Oncology; Hannover Medical School; Hannover Germany

16. Copenhagen General Population Study; Herlev Hospital; Herlev Denmark

17. Department of Clinical Biochemistry; Herlev Hospital, Copenhagen University Hospital; Herlev Denmark

18. Faculty of Health and Medical Sciences; University of Copenhagen; Copenhagen Denmark

19. Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology; Stuttgart Germany

20. University of Tübingen; Tübingen Germany

21. German Cancer Consortium; German Cancer Research Center (DKFZ); Heidelberg Germany

22. Division of Preventive Oncology; German Cancer Research Center (DKFZ); Heidelberg Germany

23. Division of Cancer Epidemiology and Genetics; National Cancer Institute; Rockville MD

24. Antoni Van Leeuwenhoek Hospital, Netherlands Cancer Institute; Amsterdam The Netherlands

25. Institute for Prevention and Occupational Medicine of the German Social Accident Insurance; Bochum Germany

26. Division of Molecular Genetic Epidemiology; German Cancer Research Center; Heidelberg Germany

27. Molecular Epidemiology Group; German Cancer Research Center; Heidelberg Germany

28. Antoni Van Leeuwenhoek Hospital; Netherlands Cancer Institute; Amsterdam The Netherlands

29. Division of Cancer Epidemiology; German Cancer Research Center; Heidelberg Germany

30. Department of Biomedical Sciences; Seoul National University College of Medicine; Seoul Korea

31. Cancer Research Institute; Seoul National University College of Medicine; Seoul Korea

32. Department of Laboratory Medicine and Pathology; Mayo Clinic; Rochester MN

33. Sheffield Cancer Research Centre; Department of Oncology; University of Sheffield; Sheffield United Kingdom

34. Academic Unit of Pathology; Department of Neuroscience; University of Sheffield; Sheffield United Kingdom

35. Department of Medical Epidemiology and Biostatistics; Karolinska Institutet; Stockholm Sweden

36. Separtment of Pathology; Leiden University Medical Center; Leiden The Netherlands

37. Department of Human Genetics; Leiden University Medical Center; Leiden The Netherlands

38. Centre Hospitalier Universitaire De Québec Research Center, Laval University; Québec City Canada

39. Gynaecology Research Unit; Hannover Medical School; Hannover Germany

40. David Geffen School of Medicine; Department of Medicine Division of Hematology and Oncology; University of California at Los Angeles; Los Angeles CA

41. Division of Cancer Studies; Breakthrough Breast Cancer Research Centre, Institute of Cancer Research; London United Kingdom

42. Department of Breast Surgery; Herlev Hospital, Copenhagen University Hospital; Herlev Denmark

43. Molecular Diagnostics Laboratory; IRRP, National Centre for Scientific Research “Demokritos,”; Athens Greece

44. International Agency for Research on Cancer; Lyon France

45. Division of Genetics and Epidemiology; Institute of Cancer Research; London United Kingdom

46. Department of Surgery; Oulu University Hospital and University of Oulu; Oulu Finland

47. Environmental Epidemiology of Cancer; Center for Research in Epidemiology and Population Health, INSERM; Villejuif France

48. University Paris-Sud; Villejuif France

49. Department of Preventive Medicine, Keck School of Medicine; University of Southern California; Los Angeles CA

50. Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ); Heidelberg Germany

51. Saw Swee Hock School of Public Health; National University of Singapore; Singapore Singapore

52. Department of Surgery; National University Health System; Singapore Singapore

53. Department of Medical Oncology; Erasmus MC Cancer Institute; Rotterdam The Netherlands

54. Division of Gynaecology and Obstetrics; Technische Universität München; Munich Germany

55. Institute of Biomedical Sciences, Academia Sinica; Taipei Taiwan

56. Division of Epidemiology and Prevention; Aichi Cancer Center Research Institute; Aichi Japan

57. Department of Genetics and Pathology; Pomeranian Medical University; Szczecin Poland

58. Institute of Human Genetics; Pontificia Universidad Javeriana; Bogota Colombia

59. Department of Preventive Medicine; Seoul National University College of Medicine; Seoul Korea

60. Department of Obstetrics and Gynecology; Helsinki University Central Hospital, University of Helsinki; Helsinki Finland

61. Prosserman Centre for Health Research; Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Toronto ON Canada

62. Division of Epidemiology, Dalla Lana School of Public Health; University of Toronto; Toronto ON Canada

63. School of Medicine; Institute of Clinical Medicine, Pathology and Forensic Medicine and Cancer Center of Eastern Finland, University of Eastern Finland; Kuopio 70210 Finland

64. Imaging Center, Department of Clinical Pathology; Kuopio University Hospital; Kuopio 70210 Finland

65. Vesalius Research Center; Leuven Belgium

66. Laboratory for Translational Genetics; Department of Oncology; University of Leuven; Leuven Belgium

67. Department of Molecular Medicine and Surgery; Karolinska Institutet; Stockholm Sweden

68. Division of Health Sciences; Warwick Medical School, Warwick University; Coventry United Kingdom

69. Unit of Medical Genetics; Department of Preventive and Predictive Medicine; Fondazione IRCCS Istituto Nazionale Dei Tumori (INT); Milan Italy

70. University of Hawaii Cancer Center; Honolulu HI

71. Department of Oncology-Pathology; Karolinska Institutet; Stockholm Sweden

72. National Center for Tumor Diseases, University of Heidelberg; Heidelberg Germany

73. Department of Obstetrics and Gynecology; University of Heidelberg; Heidelberg Germany

74. Department of Preventive Medicine; Kyushu University Faculty of Medical Sciences; Fukuoka Japan

75. Anatomical Pathology; The Alfred Hospital; Melbourne VIC Australia

76. Institute of Population Health, University of Manchester; Manchester United Kingdom

77. Beckman Research Institute of City of Hope; Duarte CA

78. Department of Genetics; Institute for Cancer Research, Oslo University Hospital; Oslo Norway

79. K.G. Jebsen Center for Breast Cancer Research; Institute for Clinical Medicine, Faculty of Medicine, University of Oslo; Oslo Norway

80. Department of Health Sciences Research; Mayo Clinic; Rochester MN

81. Division of Breast Cancer Research; Institute of Cancer Research; London United Kingdom

82. Department of Clinical Genetics; Erasmus University Medical Center; Rotterdam The Netherlands

83. IFOM, The FIRC Institute of Molecular Oncology; Milan Italy

84. Department of Pathology; National University Health System; Singapore

85. National Cancer Institute; Bangkok Thailand

86. Research Oncology, Guy's Hospital, King's College London; London United Kingdom

87. Division of Molecular Gyneco-Oncology, Department of Gynaecology and Obstetrics; University Hospital of Cologne; Cologne Germany

88. Center for Integrated Oncology; University Hospital of Cologne; Cologne Germany

89. Center for Molecular Medicine; University Hospital of Cologne; Cologne Germany

90. Center of Familial Breast and Ovarian Cancer; University Hospital of Cologne; Cologne Germany

91. School of Public Health; China Medical University; Taichung Taiwan

92. Taiwan Biobank; Institute of Biomedical Sciences; Academia Sinica Taipei 115 Taiwan

93. Cancer Center and Department of Surgery; Chung-Ho Memorial Hospital, Kaohsiung Medical University; Kaohsiung Taiwan

94. Department of Pathology; The University of Melbourne; Melbourne VIC Australia

95. Division of Genetics and Epidemiology and Division of Breast Cancer Research; Institute of Cancer Research; London United Kingdom

96. Cancer Research Initiatives Foundation; Subang Jaya Selangor Malaysia

97. Breast Cancer Research Unit; Cancer Research Institute, University Malaya Medical Centre; Kuala Lumpur Malaysia

98. Department of Molecular Virology, Immunology and Medical Genetics; Comprehensive Cancer Center, The Ohio State University; Columbus OH

99. Department of Surgical Oncology; Leiden University Medical Center; Leiden The Netherlands

100. Wellcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre; University of Oxford; Oxford United Kingdom

101. Laboratory of Cancer Genetics and Tumor Biology; Department of Clinical Chemistry; University of Oulu; Oulu Finland

102. Laboratory of Cancer Genetics and Tumor Biology; Northern Finland Laboratory Centre NordLab; Oulu Finland

103. Servicio De Oncología Médica; Hospital Universitario La Paz; Madrid Spain

104. Shanghai Municipal Center for Disease Control and Prevention; Shanghai China

105. University Hospital Gashuisberg; Leuven Belgium

106. Singapore Eye Research Institute; National University of Singapore; Singapore Singapore

107. Department of Clinical Molecular Biology (EpiGen); Akershus University Hospital, University of Oslo (UiO); Oslo Norway

108. Peter MacCallum Cancer Centre; The University of Melbourne; East Melbourne VIC Australia

Publisher

Wiley

Subject

Cancer Research,Oncology

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