Passive immunization with anti-parathyroid hormone-related protein monoclonal antibody markedly prolongs survival time of hypercalcemic nude mice bearing transplanted human PTHrP-producing tumors

Author:

Sato Kanji,Yamakawa Yukiko,Shizume Kazuo,Satoh Tomoko,Nohtomi Kyoko,Demura Hiroshi,Akatsu Takuhiko,Nagata Naokazu,Kasahara Tadashi,Ohkawa Hiroyuki,Ohsumi Kazuoki

Publisher

Wiley

Subject

Orthopedics and Sports Medicine,Endocrinology, Diabetes and Metabolism

Reference37 articles.

1. Antibodies to parathyroid hormone-related protein lower serum calcium in athymic mouse models of malignancy-associated hypercalcemia due to human tumors;Kukreja;J Clin Invest,1988

2. Tumor resection and antibodies to parathyroid hormone-related protein cause similar changes on bone histomorphometry in hypercalcemia of cancer;Kukreja;Endocrinology,1990

3. Treatment of anti-PTH-related protein (PTHrP) antibody and anti-interleukin-1α (IL-1α) antibody of hypercalcemia in nude mice transplanted with squamous cell carcinomas producing PTHrP and IL-1α;Sato;J Bone Miner Res,1989

4. Prolonged normalization of serum calcium concentration by repeated injection of monoclonal anti-PTHrP-(1-34) antibody in hypercalcemic, tumor-bearing nude mice;Sato;J Bone Miner Res,1990

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