COVID‐19‐associated myocardial injury: A case report-Reference-Cited by-同舟云学术

COVID‐19‐associated myocardial injury: A case report

Published:2023-01-24 Issue:2 Volume:10 Page:1461-1466
ISSN:2055-5822
Container-title:ESC Heart Failure
language:en
Short-container-title:ESC Heart Failure

Author:

Tadokoro Tomonori¹,Ohta‐Ogo Keiko²,Ikeda Yoshihiko²,Sugiyama Masaya³,Katano Harutaka⁴,Hatakeyama Kinta²,Matsumoto Masanori⁵,Tashiro Hideki¹

Affiliation:

1. Department of Cardiovascular Medicine St. Mary's Hospital Kurume Japan

2. Department of Pathology National Cerebral and Cardiovascular Center Suita Japan

3. Department of Viral Pathogenesis and Controls National Center for Global Health and Medicine Ichikawa Japan

4. Department of Pathology National Institute of Infectious Disease Tokyo Japan

5. Department of Blood Transfusion Medicine Nara Medical University Nara Japan

Abstract

AbstractCoronavirus disease 2019 (COVID‐19) is often accompanied by pneumonia and can be fatal. We report a case of COVID‐19‐associated myocardial injury mimicking fulminant myocarditis. Endomyocardial biopsy revealed numerous von Willebrand factor‐rich microthrombi with small myocardial necrotic areas, complement deposits in small vessels/microthrombi, and macrophage‐predominant interstitial infiltration. These findings, distinct from those of typical lymphocytic myocarditis, show diffuse endothelial injury, complement activation, and activated macrophages as characteristic features of COVID‐19‐associated pathogenesis. Dysregulated serum cytokine profiles predicting severe/critical COVID‐19‐associated myocardial injury were also determined. This case emphasizes the occurrence of fatal cardiac manifestation with microthrombotic injury in the early stage of COVID‐19.

Publisher

Wiley

Subject

Cardiology and Cardiovascular Medicine

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/ehf2.14295

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