F463L increases the potential of dofetilide on human ether-a-go-go-related gene (hERG) channels

Author:

Cheng Gong12ORCID,Wu Jine1,Han Wenqi1,Sun Chaofeng1

Affiliation:

1. Department of Cardiovascular Medicine; the First Affiliated Hospital of Xi'an Jiaotong University; Xi'an Shaanxi, 710061 P.R

2. Cardiovascular Medicine; Shaanxi Provincial People's Hospital of Xi'an Jiaotong University; Xi'an Shaanxi, 710068 China

Publisher

Wiley

Subject

Medical Laboratory Technology,Instrumentation,Histology,Anatomy

Reference26 articles.

1. HRS/EHRA Expert consensus statement on the state of genetic testing for the channelopathies and cardiomyopathies;Ackerman;Europace,2011

2. Most LQT2 mutations reduce Kv11.1 (hERG) current by a class 2 (trafficking-deficient) mechanism;Anderson;Circulation,2006

3. Functional examination of a novel long QT type 2 KCNH2 deletion;Anson;Biophysical Journal,2005

4. Chinese expert consensus on inherited cardiac ion channel disease and cardiomyopathy gene testings;Branch;Chinese Journal of Cardiology,2011

5. Assessment of the ion channel-blocking profile of the novel combined ion channel blocker AZD1305 and its proarrhythmic potential versus dofetilide in the methoxamine-sensitized rabbit in vivo;Carlsson;Journal of Cardiovascular Pharmacology,2009

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