Unraveling what makes a monoclonal antibody difficult‐to‐express: From intracellular accumulation to incomplete folding and degradation via ERAD-Reference-Cited by-同舟云学术

Unraveling what makes a monoclonal antibody difficult‐to‐express: From intracellular accumulation to incomplete folding and degradation via ERAD

Published:2019-11-15 Issue:1 Volume:117 Page:5-16
ISSN:0006-3592
Container-title:Biotechnology and Bioengineering
language:en
Short-container-title:Biotechnology and Bioengineering

Author:

Mathias Sven¹^ORCID,Wippermann Anna²,Raab Nadja¹,Zeh Nikolas¹^ORCID,Handrick René¹,Gorr Ingo³^ORCID,Schulz Patrick²,Fischer Simon⁴^ORCID,Gamer Martin²,Otte Kerstin¹

Affiliation:

1. Institute of Applied BiotechnologyUniversity of Applied Sciences Biberach Biberach Germany

2. Cell Line Development, Bioprocess Development BiologicalsBoehringer Ingelheim Pharma GmbH & Co. KG Biberach Germany

3. Early Stage Bioprocess Development, Bioprocess Development BiologicalsBoehringer Ingelheim Pharma GmbH & Co. KG Biberach Germany

4. Cell Line Development CMB, Bioprocess & Analytical DevelopmentBoehringer Ingelheim Pharma GmbH & Co. KG Biberach Germany

Publisher

Wiley

Subject

Applied Microbiology and Biotechnology,Bioengineering,Biotechnology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/bit.27196

Reference54 articles.

1. N-glycan structures: recognition and processing in the ER

2. Secretion of immunoglobulin M assembly intermediates in the presence of reducing agents

3. Glutathione- and non-glutathione-based oxidant control in the endoplasmic reticulum

4. Members of the Hsp70 Family Recognize Distinct Types of Sequences to Execute ER Quality Control

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