Affiliation:
1. Key Laboratory of Rare Earths Chinese Academy of Sciences Ganjiang Innovation Academy Chinese Academy of Sciences Ganzhou China
2. University of Science and Technology of China Hefei China
3. Division of Physical Science and Engineering (PSE) King Abdullah University of Science and Technology (KAUST) Thuwal Saudi Arabia
4. Shanghai Engineering Technology Research Center for Pharmaceutical Intelligent Equipment Shanghai Frontiers Science Research Center for Druggability of Cardiovascular noncoding RNA Institute for Frontier Medical Technology College of Chemistry and Chemical Engineering Shanghai University of Engineering Science Shanghai China
Abstract
AbstractInorganic persistent phosphors feature great potential for cancer diagnosis due to the long luminescence lifetime, low background scattering, and minimal autofluorescence. With the prominent advantages of near‐infrared light, such as deep penetration, high resolution, low autofluorescence, and tissue absorption, persistent phosphors can be used for deep bioimaging. We focus on highlighting inorganic persistent phosphors, emphasizing the synthesis methods and applications in cancer diagnostics. Typical synthetic methods such as the high‐temperature solid state, thermal decomposition, hydrothermal/solvothermal, and template methods are proposed to obtain small‐size phosphors for biological organisms. The luminescence mechanisms of inorganic persistent phosphors with different excitation are discussed and effective matrixes including galliumate, germanium, aluminate, and fluoride are explored. Finally, the current directions where inorganic persistent phosphors can continue to be optimized and how to further overcome the challenges in cancer diagnosis are summarized.
Funder
National Natural Science Foundation of China
Natural Science Foundation of Jiangxi Province