Advances in the treatment of atherosclerosis with ligand‐modified nanocarriers-Reference-Cited by-全球学者库

Advances in the treatment of atherosclerosis with ligand‐modified nanocarriers

Published:2023-12-07 Issue: Volume: Page:
ISSN:2766-8509
Container-title:Exploration
language:en
Short-container-title:Exploration

Author:

Deng Xiujiao¹²³,Wang Jinghao¹²,Yu Shanshan⁴,Tan Suiyi³,Yu Tingting¹²,Xu Qiaxin¹²,Chen Nenghua¹²,Zhang Siqi⁵,Zhang Ming‐Rong⁶,Hu Kuan⁵⁶^ORCID,Xiao Zeyu²⁷

Affiliation:

1. Department of Pharmacy The First Affiliated Hospital of Jinan University Guangzhou China

2. The Guangzhou Key Laboratory of Basic and Translational Research on Chronic Diseases Jinan University Guangzhou China

3. Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences Southern Medical University Guangzhou China

4. Department of Pharmacy Zhujiang Hospital Southern Medical University Guangzhou China

5. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China

6. Department of Advanced Nuclear Medicine Sciences, Institute of Quantum Medical, Science National Institutes for Quantum Science and Technology Chiba Japan

7. The Guangzhou Key Laboratory of Molecular and Functional Imaging for Clinical Translation Jinan University Guangzhou China

Abstract

AbstractAtherosclerosis, a chronic disease associated with metabolism, poses a significant risk to human well‐being. Currently, existing treatments for atherosclerosis lack sufficient efficiency, while the utilization of surface‐modified nanoparticles holds the potential to deliver highly effective therapeutic outcomes. These nanoparticles can target and bind to specific receptors that are abnormally over‐expressed in atherosclerotic conditions. This paper reviews recent research (2018–present) advances in various ligand‐modified nanoparticle systems targeting atherosclerosis by specifically targeting signature molecules in the hope of precise treatment at the molecular level and concludes with a discussion of the challenges and prospects in this field. The intention of this review is to inspire novel concepts for the design and advancement of targeted nanomedicines tailored specifically for the treatment of atherosclerosis.

Funder

National Natural Science Foundation of China

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/EXP.20230090

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