Combined fibre atrophy and decreased muscle regeneration capacity driven by mitochondrial DNA alterations underlie the development of sarcopenia-Reference-Cited by-同舟云学术

Combined fibre atrophy and decreased muscle regeneration capacity driven by mitochondrial DNA alterations underlie the development of sarcopenia

Published:2022-06-28 Issue:4 Volume:13 Page:2132-2145
ISSN:2190-5991
Container-title:Journal of Cachexia, Sarcopenia and Muscle
language:en
Short-container-title:J cachexia sarcopenia muscle

Author:

Kimoloi Sammy¹²,Sen Ayesha¹,Guenther Stefan³,Braun Thomas³,Brügmann Tobias⁴⁵,Sasse Philipp⁵,Wiesner Rudolf J.¹⁶⁷^ORCID,Pla‐Martín David¹^ORCID,Baris Olivier R.¹⁸^ORCID

Affiliation:

1. Institute of Vegetative Physiology University of Cologne, Faculty of Medicine and University Clinics Köln Germany

2. Department of Medical Laboratory Sciences Masinde Muliro University of Science and Technology Kakamega Kenya

3. Max Planck Institute for Heart and Lung Research Bad Nauheim Germany

4. Institute for Cardiovascular Physiology University Medical Center Göttingen Germany

5. Institute of Physiology I, Medical Faculty University of Bonn Bonn Germany

6. Center for Molecular Medicine Cologne University of Cologne Köln Germany

7. Cologne Excellence Cluster on Cellular Stress Responses in Aging‐associated Diseases (CECAD) University of Cologne Köln Germany

8. Equipe MitoLab, UMR CNRS 6015, INSERM U1083, Institut MitoVasc Université d'Angers Angers France

Funder

Deutsche Forschungsgemeinschaft

Deutscher Akademischer Austauschdienst

Publisher

Wiley

Subject

Physiology (medical),Orthopedics and Sports Medicine

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/jcsm.13026

Reference40 articles.

1. The multifaceted contributions of mitochondria to cellular metabolism

2. Mitochondrial abnormalities are more frequent in muscles undergoing sarcopenia

3. Accumulation of Mitochondrial DNA Deletion Mutations in Aged Muscle Fibers: Evidence for a Causal Role in Muscle Fiber Loss

4. Mitochondrial DNA deletion mutations increase exponentially with age in human skeletal muscle

5. Mitochondrial DNA–Deletion Mutations Accumulate Intracellularly to Detrimental Levels in Aged Human Skeletal Muscle Fibers

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