Impacts of age, diabetes, and hypertension on serum endothelial monocyte‐activating polypeptide‐II after prolonged work in the heat

Author:

Journeay W. Shane123ORCID,McCormick James J.4,King Kelli E.4,Notley Sean R.4ORCID,Goulet Nicholas45ORCID,Fujii Naoto6,Amano Tatsuro7,Kenny Glen P.48ORCID

Affiliation:

1. Department of Medicine Dalhousie Medicine New Brunswick & Dalhousie University Saint John New Brunswick Canada

2. Department of Medicine, Division of Physical Medicine & Rehabilitation University of Toronto Toronto Ontario Canada

3. Providence Healthcare—Unity Health Toronto Toronto Ontario Canada

4. Human and Environmental Physiology Research Unit, School of Human Kinetics University of Ottawa Ottawa Ontario Canada

5. Behavioural and Metabolic Research Unit, School of Human Kinetics University of Ottawa Ottawa Ontario Canada

6. Faculty of Health and Sport Sciences University of Tsukuba Tsukuba Japan

7. Laboratory for Exercise and Environmental Physiology, Faculty of Education Niigata University Niigata Japan

8. Clinical Epidemiology Program Ottawa Hospital Research Institute Ottawa Ontario Canada

Abstract

AbstractBackgroundWith rising temperature extremes, older workers are becoming increasingly vulnerable to heat‐related injuries because of age‐ and disease‐associated decrements in thermoregulatory function. Endothelial monocyte‐activating polypeptide‐II (EMAP‐II) is a proinflammatory cytokine that has not yet been well‐characterized during heat stress, and which may mediate the inflammatory response to high levels of physiological strain.MethodsWe evaluated serum EMAP‐II concentrations before and after 180 min of moderate‐intensity work (200 W/m2) in temperate (wet‐bulb globe temperature [WBGT] 16°C) and hot (WBGT 32°C) environments in heat‐unacclimatized, healthy young (n = 13; mean [SD]; 22 [3] years) and older men (n = 12; 59 [4] years), and unacclimatized older men with hypertension (HTN) (n = 10; 60 [4] years) or type 2 diabetes (T2D) (n = 9; 60 [5] years). Core temperature and heart rate were measured continuously.ResultsIn the hot environment, work tolerance time was lower in older men with HTN and T2D compared to healthy older men (bothp < 0.049). While core temperature and heart rate reserve increased significantly (p < 0.001), they did not differ across groups. End‐exercise serum EMAP‐II concentrations were higher in young men relative to their older counterparts due to higher baseline levels (bothp ≤ 0.02). Elevations in serum EMAP‐II concentrations were similar between healthy older men and older men with HTN, while serum EMAP‐II concentrations did not change in older men with T2D following prolonged work in the heat.ConclusionSerum EMAP‐II concentrations increased following prolonged moderate‐intensity work in the heat and this response is influenced by age and the presence of HTN or T2D.

Funder

Canadian Institutes of Health Research

Government of Ontario

Publisher

Wiley

Subject

Public Health, Environmental and Occupational Health

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