Palbociclib plus endocrine therapy in HER2 negative, hormonal receptor‐positive, advanced breast cancer: A real‐world experience

Author:

Pizzuti Laura1,Giordano Antonio2,Michelotti Andrea3,Mazzotta Marco4,Natoli Clara5,Gamucci Teresa67,Angelis Claudia3,Landucci Elisabetta3,Diodati Lucrezia3,Iezzi Laura5,Mentuccia Lucia6,Fabbri Agnese8,Barba Maddalena1,Sanguineti Giuseppe9,Marchetti Paolo410,Tomao Silverio11,Mariani Luciano12,Paris Ida13,Lorusso Vito14,Vallarelli Simona14,Cassano Alessandra15,Aroldi Francesca15,Orlandi Armando15,Moscetti Luca16,Sergi Domenico1,Sarobba Maria Giuseppina17,Tonini Giuseppe18,Santini Daniele18,Sini Valentina19,Veltri Enzo20,Vaccaro Angela5,Ferrari Laura5,Tursi Michele4,Tinari Nicola4,Grassadonia Antonino4,Greco Filippo21,Botticelli Andrea2,Verde Nicla22,Zamagni Claudio23,Rubino Daniela23,Cortesi Enrico24,Magri Valentina24,Pomati Giulia24,Scagnoli Simone24,Capomolla Elisabetta25,Kayal Ramy26,Scinto Angelo Fedele27,Corsi Domenico27,Cazzaniga Marina28,Laudadio Lucio29,Forciniti Samantha29,Mancini Maria29,Carbognin Luisa30,Seminara Patrizia10,Barni Sandro31,Samaritani Riccardo32,Roselli Mario33,Portarena Ilaria33,Russo Antonio34ORCID,Ficorella Corrado35,Cannita Katia35,Carpano Silvia1,Pistelli Mirco36,Berardi Rossana36,Maria Ruggero37,Sperduti Isabella38,Ciliberto Gennaro39,Vici Patrizia1ORCID

Affiliation:

1. Division of Medical Oncology 2 IRCCS Regina Elena National Cancer Institute Rome Italy

2. Department of Clinical and Molecular Medicine “Sapienza” University of Rome, Azienda Ospedaliera Sant'Andrea Rome Italy

3. UO Oncologia Medica I, Ospedale S. Chiara, Dipartimento di Oncologia Dei Trapianti e Delle Nuove Tecnologie, Azienda Ospedaliera Universitaria Pisana Pisa Italy

4. Department of Medical, Oral and Biotechnological Sciences Centro Scienze Dell'Invecchiamento e Medicina Traslazionale‐CeSI‐MeT Chieti Italy

5. Medical Oncology Unit SS Trinità Hospital, Loc. San MarcianoHospital Sora Frosinone Italy

6. Medical Oncology Unit SS Trinità Hospital Sora Italy

7. Medical Oncology Sandro Pertini Hospital Rome Italy

8. Medical Oncology Unit Belcolle Hospital Viterbo Italy

9. Department of Radiation Oncology IRCCS Regina Elena National Cancer Institute Rome Italy

10. Department of Clinical and Molecular Medicine, A Oncology Division “Sapienza” University of Rome Rome Italy

11. Department of Clinical and Molecular Medicine, A Oncology Division La “Sapienza” University of Rome Rome Italy

12. HPV Unit, Department of Gynaecologic Oncology IRCCS Regina Elena National Cancer Institute Rome Italy

13. Gynecology Oncology Unit Catholic University of the Sacred Heart Rome Italy

14. Division of Medical Oncology IRCCS, Giovanni Paolo II Hospital Bari Italy

15. Department of Medical Oncology Catholic University of Sacred Heart Rome Italy

16. Division of Medical Oncology, Department of Oncology and Hematology University Hospital of Modena Modena Italy

17. Division of Medical Oncology Ospedale San Francesco Nuoro Italy

18. Department of Oncology University Campus Biomedico of Rome Rome Italy

19. Oncology Unit ASL Roma 1, Santo Spirito Hospital Rome Italy

20. Division of Medical Oncology Ospedale S. Maria Goretti Latina Italy

21. ASST Fatebenefratelli Sacco PO Fatebenefratelli Department of Oncology Milan Italy

22. Department of Oncology ASST Fatebenefratelli Sacco PO Fatebenefratelli Milan Italy

23. SSD Oncologia Medica “Addarii” S. Orsola‐Malpighi Hospital Bologna Italy

24. Medical Oncology Policlinico Umberto I, Sapienza, University of Rome Rome Italy

25. Medical Oncology Ospedale “Parodi‐Delfino” Colleferro Italy

26. Department of Radiology IRCCS Regina Elena National Cancer Institute Rome Italy

27. Medical Oncology Unit Ospedale San Pietro Fatebenefratelli Rome Italy

28. Oncology Unit ASST Monza Monza Italy

29. Medical Oncology Ospedale F. Renzetti Lanciano Italy

30. Department of Pathology, Surgery and Oncology “Mater Salutis” Hospital, ULSS21 Verona Italy

31. Department of Oncology Oncology Unit, ASST Bergamo Ovest Treviglio Italy

32. Medical Oncology Unit “Regina Margherita” Hospital Rome Italy

33. Medical Oncology Unit, Department of Systems Medicine Tor Vergata Clinical Center University Hospital, Tor Vergata University Hospital Rome Italy

34. Department of Surgical, Oncological and Oral Sciences, Section of Medical Oncology University of Palermo Palermo Italy

35. Medical Oncology Department S. Salvatore Hospital, University of L'Aquila L'Aquila Italy

36. Azienda Ospedaliero Universitaria Ospedali Riuniti Clinica di Oncologia, Università Politecnica delle Marche Ancona Italy

37. Institute of General Pathology, Catholic University of the Sacred Heart Rome Italy

38. Bio‐statistics Unit IRCCS Regina Elena National Cancer Institute Rome Italy

39. Scientific Direction IRCCS Regina Elena National Cancer Institute Rome Italy

Publisher

Wiley

Subject

Cell Biology,Clinical Biochemistry,Physiology

Reference30 articles.

1. Benefit from palbociclib and fulvestrant based on previous fulvestrant and/or everolimus treatment. Based on a cohort of over 200 patients treated in a French compassionate program;Arnedos M.;San Antonio Breast Cancer Symposium,2017

2. Efficacy and safety of palbociclib in heavily pretreated patients with HR+/HER2- metastatic breast cancer

3. Retrospective assessment of treatment patterns and outcomes associated with palbociclib plus letrozole for postmenopausal women with HR+/HER2–advanced breast cancer enrolled in an early access program;Brufsky A.;San Antonio Breast Cancer Symposium,2018

4. Real world data on use of palbociclib in hormone‐receptor (ER) positive HER2 negative metastatic breast cancer (MBC) among Asian patients;Chiu J.;Annals of Oncolology,2017

5. The impact of dose delays and reductions on toxicity and progression free survival (PFS) in patients receiving palbociclib;Clifton K. K.;San Antonio Breast Cancer Symposium,2017

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