Blimp1 suppressed <scp>CD4</scp> <sup>+</sup> T cells‐induced activation of fibroblast‐like synoviocytes by upregulating <scp>IL</scp> ‐10 via the rho pathway-Reference-Cited by-同舟云学术

Blimp1 suppressed CD4 ⁺ T cells‐induced activation of fibroblast‐like synoviocytes by upregulating IL ‐10 via the rho pathway

Published:2022-10 Issue:1 Volume:38 Page:146-158
ISSN:1520-4081
Container-title:Environmental Toxicology
language:en
Short-container-title:Environmental Toxicology

Author:

Meng Qingliang¹,Wen Zhike²,Meng Wanting³,Bian Hua⁴,Gu Huimin¹,Zuo Ruiting¹,Zhan Junping¹,Wang Huilian¹,Miao Xiyun¹,Fan Wei¹,Zhou Zipeng¹,Zheng Fuzeng¹,Wang Liying²,Su Xiao²,Ma Junfu¹^ORCID

Affiliation:

1. Department of Rheumatology, Henan Province Hospital of Traditional Chinese Medicine (The Second Affiliated Hospital of Henan University of Traditional Chinese Medicine) Henan University of Traditional Chinese Medicine Zhengzhou China

2. Henan Province Hospital of Traditional Chinese Medicine (The Second Affiliated Hospital of Henan University of Traditional Chinese Medicine) Henan University of Traditional Chinese Medicine Zhengzhou China

3. Shanghai Municipal Hospital of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine Shanghai China

4. Zhang Zhongjing School of Chinese Medicine Nanyang Institute of Technology Nanyang China

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Health, Toxicology and Mutagenesis,Management, Monitoring, Policy and Law,Toxicology,General Medicine

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/tox.23672

Reference34 articles.

1. CD147-mediated chemotaxis of CD4+CD161+ T cells may contribute to local inflammation in rheumatoid arthritis

2. Synovial IL-21/TNF-producing CD4 + T cells induce joint destruction in rheumatoid arthritis by inducing matrix metalloproteinase production by fibroblast-like synoviocytes

3. TIGIT overexpression diminishes the function of CD4 T cells and ameliorates the severity of rheumatoid arthritis in mouse models

4. Tofacitinib attenuates arthritis manifestations and reduces the pathogenic CD4 T cells in adjuvant arthritis rats

5. Effects of mammalian target of rapamycin and aryl hydrocarbon receptor‐mediating autophagy signaling on the balance of Th17/Treg cells during perinatal bisphenol A exposure in female offspring mice

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1. Exosomal lncRNA TUG1 derived from BMSC ameliorate collagen-induced arthritis via BLIMP1-mediated Th17/Treg balance;International Immunopharmacology;2024-12

2. Augmenting regulatory T cells: new therapeutic strategy for rheumatoid arthritis;Frontiers in Immunology;2024-01-23