Direct and cytokine-mediated effects of albumin-fused growth hormone, TV-1106, on CYP enzyme expression in human hepatocytes in vitro

Author:

Czerwiński Maciej1ORCID,Amunom Immaculate1,Piryatinsky Victor2,Hallak Hussein2,Sahly Yousif2,Bar-Ilan Oren2,Bolliger Paul13,Bassan Merav2

Affiliation:

1. Sekisui XenoTech, LLC; Kansas City KS USA

2. Teva Pharmaceutical Industries Ltd; Petach Tikva Israel

3. KCAS; Shawnee KS USA

Publisher

Wiley

Subject

General Pharmacology, Toxicology and Pharmaceutics,Neurology

Reference26 articles.

1. Food and Drug Administration (US) and (CDER) CfDEaR Guidance for industry: drug interaction studies-study design, data analysis, implications for dosing, and labeling recommendations, draft guidance Silver Spring, MD U.S. Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research (CDER) 2012 79

2. Critical review of preclinical approaches to investigate cytochrome P450-mediated therapeutic protein drug-drug interactions and recommendations for best practices: a white paper;Evers;Drug Metab Dispos,2013

3. Albutropin: a growth hormone-albumin fusion with improved pharmacokinetics and pharmacodynamics in rats and monkeys;Osborn;Eur J Pharmacol,2002

4. Albumin and its application in drug delivery;Sleep;Expert Opin Drug Deliv,2014

5. Albutropin in adults with growth hormone deficiency;Klibanski;Growth Horm IGF Res,2002

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