Alpha‐1 Antitrypsin Deficiency Liver Disease, Mutational Homogeneity Modulated by Epigenetic Heterogeneity With Links to Obesity

Author:

Wang Liguo1,Marek George W.2,Hlady Ryan A.3ORCID,Wagner Ryan T.3,Zhao Xia3,Clark Virginia C.4,Fan Alex Xiucheng2,Liu Chen5,Brantly Mark2,Robertson Keith D.36ORCID

Affiliation:

1. Division of Biomedical Statistics and Informatics, Department of Health Science Research Mayo Clinic Rochester MN

2. Division of Pulmonary, Critical Care & Sleep Medicine, College of Medicine University of Florida Gainesville FL

3. Department of Molecular Pharmacology and Experimental Therapeutics Mayo Clinic Rochester MN

4. Division of Gastroenterology, Hepatology & Nutrition University of Florida Gainesville FL

5. Department of Pathology and Laboratory Medicine New Jersey Medical School, Rutgers, The State University of New Jersey Newark NJ

6. Center for Individualized Medicine Epigenomics Program Mayo Clinic Rochester MN

Funder

Alpha-1 Foundation

Publisher

Wiley

Subject

Hepatology

Reference37 articles.

1. Clinical features and molecular characteristics of alpha 1‐antitrypsin deficiency;Blank CA;Ann Allergy,1994

2. α1-Antitrypsin deficiency

3. Liver disease in alpha1‐antitrypsin deficiency detected by screening of 200,000 infants;Sveger T;N Engl J Med,1976

4. Alpha1‐antitrypsin deficiency in 26‐year‐old subjects: lung, liver, and protease/protease inhibitor studies;Piitulainen E;Chest,2005

5. Mortality in individuals with severe deficiency of alpha1‐antitrypsin: findings from the National Heart, Lung, and Blood Institute Registry;Stoller JK;Chest,2005

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