Versican and versikine: The dynamism of the extracellular matrix

Author:

Watanabe Hideto1ORCID

Affiliation:

1. Institute for Molecular Science of Medicine Aichi Medical University Nagakute Aichi Japan

Abstract

AbstractVersican is a large chondroitin sulfate/dermatan sulfate proteoglycan in the extracellular matrix and one of the aggrecan/lectican family. Whereas versican is constitutively expressed and serves as a structural macromolecule in some tissues, it is transiently expressed at high levels when the extracellular matrix dynamically changes. There, versican plays an important role in forming the provisional matrix, which is replaced with the “authentic” extracellular matrix, that is, the matrix as it should be. ADAMTS‐1, 4, 5, 9, 15, and 20 cleave versican core protein and are therefore named versicanases. These proteinases have been believed to play a critical role in versican turnover. A cleaved N‐terminal fragment harbors biological functions, and it is termed “versikine.” This review discusses recent advances in the research on the in vivo function of versican and versikine generated by versicanases.

Funder

Japan Society for the Promotion of Science

Publisher

Wiley

Cited by 3 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Versican maintains the homeostasis of adipose tissues and regulates energy metabolism;Biochemical and Biophysical Research Communications;2024-10

2. Versican and Versikine: Regulator of Matrix Dynamism;Trends in Glycoscience and Glycotechnology;2024-07-25

3. Versican and Versikine: Regulator of Matrix Dynamism;Trends in Glycoscience and Glycotechnology;2024-07-25

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