Inhibitory effects of retigabine, a Kv7 channel activator, on mechanosensitive primary bladder afferent activities and nociceptive behaviors in rats

Author:

Aizawa Naoki1,Wakamatsu Daisuke2,Kida Jun2,Otsuki Takeya2,Saito Yasuho3,Matsuya Hidekazu2,Homma Yukio3,Igawa Yasuhiko1

Affiliation:

1. Department of Continence Medicine; The University of Tokyo Graduate School of Medicine; Tokyo Japan

2. Discovery Research Laboratories 4; Department of Biology & Pharmacology; ONO Pharmaceutical Co., Ltd.; Osaka Japan

3. Department of Urology; The University of Tokyo Graduate School of Medicine; Tokyo Japan

Funder

Grants-in-Aid for Scientific Research

Publisher

Wiley

Subject

Urology,Neurology (clinical)

Reference19 articles.

1. Cromakalim, nicorandil and pinacidil: Novel drugs which open potassium channels in smooth muscle;Hamilton;Gen Pharmacol,1989

2. The pharmacology of potassium channels and their therapeutic potential;Cook;Trends Pharmacol Sci,1988

3. The potassium channel openers: A new class of vasorelaxants;Weston;Blood Vessels,1990

4. Pharmacology of lower urinary tract smooth muscles and penile erectile tissues;Andersson;Pharmacol Rev,1993

5. Openers of small conductance calcium-activated potassium channels selectively enhance NO-mediated bradykinin vasodilatation in porcine retinal arterioles;Dalsgaard;Br J Pharmacol,2010

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