A fully adjusted two-stage procedure for rank-normalization in genetic association studies

Author:

Sofer Tamar12ORCID,Zheng Xiuwen3,Gogarten Stephanie M.3,Laurie Cecelia A.3,Grinde Kelsey3,Shaffer John R.45,Shungin Dmitry67,O’Connell Jeffrey R.8,Durazo-Arvizo Ramon A.9,Raffield Laura10,Lange Leslie11,Musani Solomon12,Vasan Ramachandran S.13141516,Cupples L. Adrienne16,Reiner Alexander P.17,Laurie Cathy C.3,Rice Kenneth M.3ORCID,

Affiliation:

1. Department of Medicine; Harvard Medical School; Boston Massachusetts

2. Division of Sleep and Circadian Disorders; Brigham and Women’s Hospital; Boston Massachusetts

3. Department of Biostatistics; University of Washington; Seattle Washington

4. Department of Human Genetics; Graduate School of Public Health, University of Pittsburgh; Pittsburgh Pennsylvania

5. Department of Oral Biology; School of Dental Medicine, Center for Craniofacial and Dental Genetics, University of Pittsburgh; Pittsburgh Pennsylvania

6. Broad Institute of Harvard and MIT; Cambridge Massachusetts

7. Department of Odontology; Umeå University; Umeå Sweden

8. Department of Medicine; Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine; Baltimore Maryland

9. Department of Public Health Sciences; Stritch School of Medicine, Loyola University Chicago; Maywood Illinois

10. Department of Genetics; University of North Carolina; Chapel Hill North Carolina

11. Department of Medicine; University of Colorado Denver, Anschutz Medical Campus; Aurora Colorado

12. Department of Medicine; University of Mississippi Medical Center; Jackson Mississippi

13. Department of Medicine; Boston University Schools of Medicine; Boston Massachusetts

14. Department of Epidemiology; Boston University School of Public Health; Boston Massachusetts

15. Boston University’s and National Heart, Lung, and Blood Institute’s Framingham Heart Study; Framingham Massachusetts

16. Department of Biostatistics; Boston University School of Public Health; Boston Massachusetts

17. Department of Epidemiology; School of Public Health, University of Washington; Seattle Washington

Funder

National Heart, Lung, and Blood Institute

National Human Genome Research Institute

National Institute of Diabetes and Digestive and Kidney Diseases

School of Medicine, University of North Carolina at Chapel Hill

University of Miami

Albert Einstein College of Medicine, Yeshiva University

University of Illinois at Chicago

San Diego State University

Jackson State University

Tougaloo College

University of Mississippi Medical Center

National Institute of Health

Publisher

Wiley

Subject

Genetics(clinical),Epidemiology

Reference20 articles.

1. Further evidence for a gene influencing spatial ability;Ashton;Behavior Genetics,1987

2. The effect of phenotypic outliers and non-normality on rare-variant association testing;Auer;European Journal of Human Genetics,2016

3. Rank-based inverse normal transformations are increasingly used, but are they merited?;Beasley;Behavior Genetics,2009

4. Loss of power in two-stage residual-outcome regression analysis in genetic association studies;Che;Genetic Epidemiology,2012

5. Conomos , M. P. Gogarten , S. M. Brown , L. Chen , H. Rice , K. Sofer , T. Yu , C. 2018

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