Enhancing value of clinical pharmacodynamics in oncology drug development: An alliance between quantitative pharmacology and translational science

Author:

Venkatakrishnan K1,Ecsedy JA2

Affiliation:

1. Quantitative Clinical Pharmacology; Takeda Pharmaceuticals International Co; Cambridge Massachusetts USA

2. Translational and Biomarker Research; Takeda Pharmaceuticals International Co; Cambridge Massachusetts USA

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference77 articles.

1. Thomas , D.W. et al Clinical Development Success Rates 2006-2015

2. Failures in phase III: causes and consequences;Seruga;Clin Cancer Res.,2015

3. Proof of concept: a PhRMA position paper with recommendations for best practice;Cartwright;Clin Pharmacol Ther.,2010

4. Challenges of phase 1 clinical trials evaluating immune checkpoint-targeted antibodies;Postel-Vinay;Ann Oncol.,2016

5. Expansion cohorts in first-in-human solid tumor oncology trials;Theoret;Clin Cancer Res.,2015

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