Endocrine Complications and Paraneoplastic Syndromes

Abstract

OverviewTransformation of normal cells results in activation and/or suppression of a number of hormonally active genes. This chapter outlines the several clinical endocrine paraneoplastic syndromes and their appropriate management. Treatment of cancer results in a number of endocrine or metabolic manifestations, most of which are related to hormone deficiency or drug‐related toxicity. The introduction of targeted therapy that disrupts signaling pathways and immunotherapy, contrary to expectations, has actually increased the number of endocrine manifestations. This chapter will chronicle the major new endocrine toxicities in addition to those observed with older cytotoxic chemotherapies and radiation.