Neoplasms of the Small Intestine, Vermiform Appendix, and Peritoneum and Carcinoma of the Colon and Rectum

Abstract

OverviewCancers of the small bowel, large bowel, and appendix compromise a multitude of distinct pathologic entities and clinical presentations. While tumors of the small bowel are uncommon with <3% of all alimentary tract tumors and 0.4% of all malignancies arise in the small bowel, colon cancer is the third most common malignant tumor and the fourth most common cause of cancer death worldwide. Although adenocarcinoma remains the common pathology, many advances have been made regarding our diagnoses and management of carcinoid tumors and even to a larger degree in gastrointestinal stromal tumors. Additional advances include our understanding of genetics, new imaging modalities, and minimally invasive surgeries. This chapter will provide a comprehensive review of the management and treatment of cancers of the small bowel, large bowel, and appendix.