Synthesis and biological investigation of protein phosphatase 2A ‐activating compounds with dimeric tail as non‐small cell lung cancer cell death agents
Author:
Affiliation:
1. College of Pharmacy Mokpo National University Jeonnam Korea
2. College of Pharmacy, Research Institute of Pharmaceutical Sciences Kyungpook National University Daegu Korea
3. Department of Food and Nutrition Eulji University Seongnam Korea
Funder
Mokpo National University
Publisher
Wiley
Subject
General Chemistry
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1002/bkcs.12661
Reference17 articles.
1. Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis
2. Potential anti-tumor effects of FTY720 associated with PP2A activation: a brief review
3. Novel Immunomodulator FTY720 Is Phosphorylated in Rats and Humans To Form a Single Stereoisomer. Identification, Chemical Proof, and Biological Characterization of the Biologically Active Species and Its Enantiomer
4. Sphingolipid metabolism in cancer signalling and therapy
5. (R)-FTY720 methyl ether is a specific sphingosine kinase 2 inhibitor: Effect on sphingosine kinase 2 expression in HEK 293 cells and actin rearrangement and survival of MCF-7 breast cancer cells
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