Transporters in Drug Development: 2018 ITC Recommendations for Transporters of Emerging Clinical Importance

Author:

Zamek-Gliszczynski Maciej J.1,Taub Mitchell E.2,Chothe Paresh P.3,Chu Xiaoyan4,Giacomini Kathleen M.5,Kim Richard B.6,Ray Adrian S.7,Stocker Sophie L.8,Unadkat Jashvant D.9,Wittwer Matthias B.10,Xia Cindy11,Yee Sook-Wah5,Zhang Lei12,Zhang Yan13,

Affiliation:

1. Quantitative Drug Disposition, GlaxoSmithKline; King of Prussia Pennsylvania USA

2. Drug Metabolism and Pharmacokinetics, Boehringer Ingelheim; Ridgefield Connecticut USA

3. Drug Metabolism and Pharmacokinetics, Vertex Pharmaceuticals; Boston Massachusetts USA

4. Department of Pharmacokinetics; Pharmacodynamics and Drug Metabolism, Merck & Co.; Kenilworth New Jersey USA

5. Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine; University of California; San Francisco California USA

6. Division of Clinical Pharmacology, Department of Medicine; Western University; London ON Canada

7. Clinical Research, Gilead Sciences; Foster City California USA

8. Department of Clinical Pharmacology & Toxicology; St Vincent's Hospital, Sydney, NSW, Australia & St Vincent's Clinical School; UNSW Sydney NSW Australia

9. Department of Pharmaceutics; University of Washington; Seattle Washington USA

10. Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche; Basel Switzerland

11. Drug Metabolism and Pharmacokinetics, Takeda Pharmaceuticals International; Cambridge Massachusetts USA

12. Office of Research and Standards, Office of Generic Drugs, Center for Drug Evaluation and Research, Food and Drug Administration; Silver Spring Maryland USA

13. Drug Metabolism Pharmacokinetics & Clinical Pharmacology, Incyte; Wilmington Delaware USA

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference103 articles.

1. Membrane transporters in drug development;International Transporter, C.;Nat. Rev. Drug Discov.,2010

2. Emerging clinical importance of hepatic organic cation transporter 1 (OCT1) in drug pharmacokinetics, dynamics, pharmacogenetic variability, and drug interactions;Zamek-Gliszczynski;Clin. Pharmacol. Ther.,2017

3. The effect of famotidine, a MATE1-selective inhibitor, on the pharmacokinetics and pharmacodynamics of metformin;Hibma;Clin. Pharmacokinet.,2016

4. Ablation of both organic cation transporter (OCT)1 and OCT2 alters metformin pharmacokinetics but has no effect on tissue drug exposure and pharmacodynamics;Higgins;Drug Metab. Dispos.,2012

5. The effect of dolutegravir on the pharmacokinetics of metformin in healthy subjects;Song;J. Acquir. Immune Defic. Syndr.,2016

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