A quality improvement initiative standardizing premedication for blood product transfusions

Author:

Shahid Sanam1,Rosenzweig Jaclyn1ORCID,Troullioud Lucas Alexandre1,McThenia Sheila S.1,Fong Christina1,Degliuomini Melanie D.1,Wuest David2,Kaicker Shipra3ORCID,Slotkin Emily K.1ORCID

Affiliation:

1. Department of Pediatrics Memorial Sloan Kettering Cancer Center New York New York USA

2. Department of Transfusion Medicine Memorial Sloan Kettering Cancer Center New York New York USA

3. Department of Pediatrics New York Presbyterian Hospital‐Weill Cornell Medical Center New York New York USA

Abstract

AbstractFor children with cancer, blood product transfusions are crucial, but can be complicated by transfusion reactions. To prevent these complications, premedication is often given, although not always evidence‐based. Herein, we describe a significant decrease in the use of premedication (72%–28%) at our institution after the implementation of standardized guidelines, without an increase in transfusion reactions (3.2% prior vs. 1.5% after standardization). Importantly, there were no severe transfusion reactions leading to hospitalization or death. Our results provide evidence in favor of more judicious use of premedication prior to transfusions in patients 21 years and younger being treated for cancer.

Publisher

Wiley

Subject

Oncology,Hematology,Pediatrics, Perinatology and Child Health

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