Challenges in optimizing sample preparation and LC-MS/MS conditions for the analysis of carglumic acid, an N-acetyl glutamate derivative in human plasma
Author:
Affiliation:
1. Department of Chemistry, School of Sciences; Gujarat University; Ahmedabad 380009 India
2. Chemistry Department; St Xavier's College; Navrangpura Ahmedabad 380009 India
Publisher
Wiley
Subject
Spectroscopy,Pharmaceutical Science,Environmental Chemistry,Analytical Chemistry
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1002/dta.1774/fullpdf
Reference15 articles.
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2. N-acetylglutamate synthetase (NAGS) deficiency;Colombo;Adv. Exp. Med. Biol.,1994
3. Role of carglumic acid in the treatment of acute hyperammonemia due to N-acetylglutamate synthase deficiency;Häberle;Ther. Clin. Risk Manag.,2011
4. Hypothesis: Proposals for the management of a neonate at risk of hyperammonaemia due to a ureacycle disorder;Leonard;Eur. J. Pediatr.,2008
5. New developments in the treatment of hyperammonemia: Emerging use of carglumic acid;Daniotti;Int. J. Gen. Med.,2011
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