Challenges in optimizing sample preparation and LC-MS/MS conditions for the analysis of carglumic acid, an N-acetyl glutamate derivative in human plasma

Author:

Sharma Primal1,Shah Priyanka A.1,Sanyal Mallika2,Shrivastav Pranav S.1ORCID

Affiliation:

1. Department of Chemistry, School of Sciences; Gujarat University; Ahmedabad 380009 India

2. Chemistry Department; St Xavier's College; Navrangpura Ahmedabad 380009 India

Publisher

Wiley

Subject

Spectroscopy,Pharmaceutical Science,Environmental Chemistry,Analytical Chemistry

Reference15 articles.

1. N-acetylglutamate synthetase deficiency: A disorder of ammonia detoxication;Bachmann;New Engl. J. Med.,1981

2. N-acetylglutamate synthetase (NAGS) deficiency;Colombo;Adv. Exp. Med. Biol.,1994

3. Role of carglumic acid in the treatment of acute hyperammonemia due to N-acetylglutamate synthase deficiency;Häberle;Ther. Clin. Risk Manag.,2011

4. Hypothesis: Proposals for the management of a neonate at risk of hyperammonaemia due to a ureacycle disorder;Leonard;Eur. J. Pediatr.,2008

5. New developments in the treatment of hyperammonemia: Emerging use of carglumic acid;Daniotti;Int. J. Gen. Med.,2011

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