Interleukin-21 Promotes Germinal Center Reaction by Skewing the Follicular Regulatory T Cell to Follicular Helper T Cell Balance in Autoimmune BXD2 Mice
Author:
Affiliation:
1. University of Alabama at; Birmingham
2. Swissmedic, Swiss Agency for Therapeutic Products; Bern Switzerland
3. University of Alabama at Birmingham and Birmingham VA Medical Center; Birmingham Alabama
Funder
Arthritis Foundation
Lupus Research Institute
NIAMS
NIH
NIH/NIAID
Rheumatology Research Foundation
VAMC
Publisher
Wiley
Subject
Immunology,Rheumatology,Immunology and Allergy
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1002/art.38735/fullpdf
Reference40 articles.
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2. The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment;Yu;Immunity,2009
3. Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages;Nurieva;Immunity,2008
4. Follicular helper T cells are required for systemic autoimmunity;Linterman;J Exp Med,2009
5. Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus;Simpson;Arthritis Rheum,2010
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