Simple and sensitive LC-MS/MS-based assay for the quantification of dimemorfan in human plasma for use in a pharmacokinetic study

Author:

Tan Hongyi1,Peng Jinfu12,Pei Qi1,Yang Liu12,Chen Jun1,Guo Chengxian1,Hua Ye1,Yuan Hong1,Yang Guoping1

Affiliation:

1. Center of Clinical Pharmacology, Third Xiangya Hospital; Central South University; Changsha Hunan 410013 China

2. School of Pharmaceutical Sciences; Central South University; Changsha Hunan 410013 China

Funder

the Program for Science and Technology Research of Hunan Province

the Health Department Foundation of Hunan Province

the National Science and Technology Major Projects

the National Scientif ic Foundation of China

Publisher

Wiley

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,General Medicine,Biochemistry,Analytical Chemistry

Reference17 articles.

1. China Food and Drug Administration Technical Guidelines: Human Bioavailability and Bioequivalence Study of Chemico-pharmaceutical Preparations 2005 http://www.sfda.gov.cn/directory/web/WS01/images/u6Rp9KpzuWxrzByMvM5cn6zuA+9PDtsi6zcn6zu+1yNCn0NTR0L6vLzK9da4tbzUrdTyLnBkZg==.pdf

2. Binding of dimemorfan to sigma-1 receptor and its anticonvulsant and locomotor effects in mice, compared with dextromethorphan and dextrorphan;Chou;Brain Research,1999

3. Dimemorfan N-demethylation by mouse liver microsomal cytochrome P450 enzymes;Chou;Life Sciences,2005

4. The oxidative metabolism of dimemorfan by human cytochrome P450 enzymes;Chou;Journal of Pharmaceutical Sciences,2010

5. European Medicines Agency Guideline on Validation of Bioanalytical Methods 2011 http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2011/08/WC500109686.pdf

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