Panax notoginseng saponins attenuate cardiomyocyte apoptosis through mitochondrial pathway in natural aging rats

Author:

Zhou Zhiyong1ORCID,Wang Jiao1,Song Yanan1,He Yumin1,Zhang Changcheng1,Liu Chaoqi1,Zhao Haixia1,Dun Yaoyan1,Yuan Ding2,Wang Ting1

Affiliation:

1. Medical College of China Three Gorges University; Yichang 443002 P. R. China

2. RENHE Hospital of China Three Gorges University; Yichang 443002 P. R. China

Funder

Open Foundation of Yichang Key Laboratory of ischemic cardiovascular and cerebrovascular disease translational medicine (Three Gorges University)

National Natural Science Foundation of China

Publisher

Wiley

Subject

Pharmacology

Reference29 articles.

1. Cardiomyopathy of aging in the mammalian heart is characterized by myocardial hypertrophy, fibrosis and a predisposition towards cardiomyocyte apoptosis and autophagy;Boyle;Experimental Gerontology,2011

2. Age-related death-survival balance in myocardium: An immunohistochemical and biochemical study;Centurione;Mechanisms of Ageing and Development,2002

3. Protective effects of trilinolein extracted from panax notoginseng against cardiovascular disease;Chan;Acta Pharmacologica Sinica,2002

4. Clinical observation on 100 cases of angina pectoris treated by Luotai;Chen;Chinese Traditional and Herbal Drugs,2002

5. Panax notoginseng saponins inhibit ischemia-induced apoptosis by activating PI3K/Akt pathway in cardiomyocytes;Chen;Journal of Ethnopharmacology,2011

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