Exploring the functional impact of mutational drift in LRRK2 gene and identification of specific inhibitors for the treatment of Parkinson disease
Author:
Affiliation:
1. Molecular and Nanomedicine Research UnitCentre for Nanoscience and NanotechnologySathyabama UniversityChennaiTamil NaduIndia
2. Department of BioinformaticsSathyabama UniversityChennaiTamil NaduIndia
Funder
Department of Science and Technology,India
Publisher
Wiley
Subject
Cell Biology,Molecular Biology,Biochemistry
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1002/jcb.26703
Reference37 articles.
1. Mutations in LRRK2 Cause Autosomal-Dominant Parkinsonism with Pleomorphic Pathology
2. Cloning of the Gene Containing Mutations that Cause PARK8-Linked Parkinson's Disease
3. Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study
4. LRRK2 and Parkinson Disease
5. Ancient Origin of the Parkinson Disease Gene LRRK2
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3. How Parkinson's disease-related mutations disrupt the dimerization of WD40 domain in LRRK2: a comparative molecular dynamics simulation study;Physical Chemistry Chemical Physics;2020
4. Molecular insights of the G2019S substitution in LRRK2 kinase domain associated with Parkinson's disease: A molecular dynamics simulation approach;Journal of Theoretical Biology;2019-05
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