Novel mechanism-based substrates of dihydrofolate reductase and the thermodynamics of ligand binding: A comparison of theory and experiment for 8-methylpterin and 6,8-dimethylpterin-Reference-Cited by-同舟云学术

Novel mechanism-based substrates of dihydrofolate reductase and the thermodynamics of ligand binding: A comparison of theory and experiment for 8-methylpterin and 6,8-dimethylpterin

Published:1993-04 Issue:4 Volume:15 Page:426-435
ISSN:0887-3585
Container-title:Proteins: Structure, Function, and Genetics
language:en
Short-container-title:Proteins

Author:

Cummins Peter L.,Gready Jill E.

Publisher

Wiley

Subject

Molecular Biology,Biochemistry,Structural Biology

Reference55 articles.

1. Dihydrofolate reductase. In: “Biological Macromolecules and Assemblies Vol 3.” and (eds.) New York: Wiley, 1987: 1-72

2. Crystal structure of human dihydrofolate reductase complexed with folate

3. Crystal structures of Escherichia coli dihydrofolate reductase: the NADP+ holoenzyme and the folate .cntdot. NADP+ ternary complex. substrate binding and a model for the transition state

4. Crystal structures of recombinant human dihydrofolate reductase complexed with folate and 5-deazafolate

5. Crystal structures of Escherichia coli and Lactobacillus casei dihydrofolate reductase refined at 1.7 A resolution. I. General features and binding of methotrexate.

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3. Importance of Substrate and Cofactor Polarization in the Active Site of Dihydrofolate Reductase;Journal of Molecular Biology;2003-03

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