Multilayer Polymer Shell Perfluoropentane Nanodroplets for Multimodal Ultrasound, Magnetic Resonance, and Optoacoustic Imaging

Author:

Maksimova Elizaveta A.1ORCID,Nozdriukhin Daniil23,Kalva Sandeep Kumar23,Lyu Shuxin234,Lafci Berkan23,Augath Mark‐Aurel3,Rudakovskaya Polina G.1,Solovev Alexander A.5,Mei Yongfeng5,Deán‐Ben Xosé Luís23,Razansky Daniel23,Gorin Dmitry A.1ORCID

Affiliation:

1. Center for Photonics Science and Engineering Skolkovo Institute of Science and Technology Bolshoy Boulevard 30, Building 1 Moscow 121205 Russia

2. Institute for Biomedical Engineering and Institute of Pharmacology and Toxicology, Faculty of Medicine University of Zürich Winterthurerstrasse 190 Zurich 8057 Switzerland

3. Institute for Biomedical Engineering Department of Information Technology and Electrical Engineering ETH Zürich, Rämistrasse 101 Zurich 8093 Switzerland

4. Department of Medical Imaging Shanxi Medical University Taiyuan 030001 China

5. Department of Materials Science Fudan University Shanghai 200433 China

Abstract

AbstractMultimodal imaging increases the value of stand‐alone modalities by enabling simultaneous multiparametric characterization of biological tissues in vivo. Particularly, optoacoustic (OA) tomography has enabled bringing optical imaging advantages to previously unattainable depths and is currently being hybridized with other imaging technologies for enhanced performance. The full potential of these multimodal imaging approaches can only be achieved with dedicated contrast agents ensuring simultaneous measurements and accurate co‐registration of the information provided. Herein, perfluoropentane‐filled nanodroplets are modified, providing excellent contrast in ultrasound imaging, by introducing shell‐embedded additives offering strong contrast in magnetic resonance and OA imaging. Magnetite nanoparticles and indocyanine green (ICG) dye are simultaneously deposited as a multilayer shell on the droplets with the layer‐by‐layer method. This results in sufficiently high amounts of magnetite (0.54 ± 0.08 mg mL−1) and ICG (0.30 ± 0.08 mg mL−1) for efficient magnetic resonance and OA detection, respectively. The high sensitivity achieved with the developed trimodal nanodroplets is first demonstrated in phantom experiments, after which their potential toxic effects, biodistribution, and clearance are examined in vitro and in vivo. Taken together, the obtained results indicate that the developed multilayer polymer shell nanodroplets are efficient hybrid contrast agents for multimodal biomedical imaging applications.

Funder

European Research Council

National Institutes of Health

Helmut Horten Stiftung

Publisher

Wiley

Subject

Condensed Matter Physics,Atomic and Molecular Physics, and Optics,Electronic, Optical and Magnetic Materials

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