Alpha‐ketoglutaric acid based polymeric particles for cutaneous wound healing-Reference-Cited by-同舟云学术

Alpha‐ketoglutaric acid based polymeric particles for cutaneous wound healing

Published:2023-03-23 Issue:9 Volume:111 Page:1372-1378
ISSN:1549-3296
Container-title:Journal of Biomedical Materials Research Part A
language:en
Short-container-title:J Biomedical Materials Res

Author:

Jaggarapu Madhan M. C. S.¹,Ghosh Deepanjan²,Johnston Tyler³,Yaron Jordan R.¹,Mangal Joslyn L.³,Inamdar Sahil¹,Gosangi Mallikarjun¹,Rege Kaushal¹²⁴⁵⁶,Acharya Abhinav P.¹²⁴⁵⁶^ORCID

Affiliation:

1. Chemical Engineering, School for the Engineering of Matter, Transport, and Energy Arizona State University Tempe Arizona 85281 USA

2. Biological Design, School for the Engineering of Matter, Transport, and Energy Arizona State University Tempe Arizona 85281 USA

3. Molecular Biosciences and Biotechnology The College of Liberal Arts and Sciences, School of Life Sciences, Arizona State University Tempe Arizona 85281 USA

4. Biomedical Engineering, School of Biological and Health Systems Engineering Arizona State University Tempe Arizona 85281 USA

5. Materials Science and Engineering, School for the Engineering of Matter, Transport, and Energy Arizona State University Tempe Arizona 85281 USA

6. Biodesign Center for Biomaterials Innovation and Translation Arizona State University Tempe Arizona 85281 USA

Abstract

AbstractMetabolites are not only involved in energy pathways but can also act as signaling molecules. Herein, we demonstrate that polyesters of alpha‐ketoglutararte (paKG) can be generated by reacting aKG with aliphatic diols of different lengths, which release aKG in a sustained manner. paKG polymer‐based microparticles generated via emulsion‐evaporation technique lead to faster keratinocyte wound closures in a scratch assay test. Moreover, paKG microparticles also led to faster wound healing responses in an excisional wound model in live mice. Overall, this study shows that paKG MPs that release aKG in a sustained manner can be used to develop regenerative therapeutic responses.

Funder

National Institutes of Health

Publisher

Wiley

Subject

Metals and Alloys,Biomedical Engineering,Biomaterials,Ceramics and Composites

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/jbm.a.37539

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