Toxicology and safety study of L‐tryptophan and its impurities for use in swine

Author:

Park Ji‐Eun12,Ko Soo Min1,Han Hyo‐Jeong1,Lee Ji‐Young1,Jeong Da Som1,Lee Dong Hyun1,Heo In Kyung2,Shin Yong Uk2,Kim Yang Hee2ORCID,Son Woo‐Chan3ORCID

Affiliation:

1. Department of Medical Science, AMIST, Asan Medical Center University of Ulsan College of Medicine Seoul Republic of Korea

2. Institute of Biotechnology CJ CheilJedang Suwon‐si Gyeonggi‐do Republic of Korea

3. Department of Pathology, Asan Medical Center University of Ulsan College of Medicine Seoul Republic of Korea

Abstract

AbstractL‐tryptophan, an essential amino acid for physiological processes, metabolism, development, and growth of organisms, is widely utilized in animal nutrition and human health as a feed additive and nutritional supplement, respectively. Despite its known benefits, safety concerns have arisen due to an eosinophilia–myalgia syndrome (EMS) outbreak linked to L‐tryptophan consumed by humans. Extensive research has established that the EMS outbreak was caused by an L‐tryptophan product that contained certain impurities. Therefore, safety validations are imperative to endorse the use of L‐tryptophan as a supplement or a feed additive. This study was conducted in tertiary hybrid [(Landrace × Yorkshire) × Duroc] pigs to assess general toxicity and potential risks for EMS‐related symptoms associated with L‐tryptophan used as a feed additive. Our investigation elucidated the relationship between L‐tryptophan and EMS in swine. No mortalities or clinical signs were observed in any animals during the administration period, and the test substance did not induce toxic effects. Hematological analysis and histopathological examination revealed no changes in EMS‐related parameters, such as eosinophil counts, lung lesions, skin lesions, or muscle atrophy. Furthermore, no test substance‐related changes occurred in other general toxicological parameters. Through analyzing the tissues and organs of swine, most of the L‐tryptophan impurities that may cause EMS were not retained. Based on these findings, we concluded that incorporating L‐tryptophan and its impurities into the diet does not induce EMS in swine. Consequently, L‐tryptophan may be used as a feed additive throughout all growth stages of swine without safety concerns.

Publisher

Wiley

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