Fetal Therapy for Congenital Pulmonary Malformations: A Prospective Population‐Based National Cohort Study-Reference-Cited by-同舟云学术

Fetal Therapy for Congenital Pulmonary Malformations: A Prospective Population‐Based National Cohort Study

Published:2024-08-13 Issue: Volume: Page:
ISSN:0197-3851
Container-title:Prenatal Diagnosis
language:en
Short-container-title:Prenatal Diagnosis

Author:

Weber Mathilde¹,Monier Isabelle²^ORCID,Rahshenas Makan²,Salomon Laurent J.³,Sananes Nicolas⁴,Castaigne Vanina⁵,Houfflin‐Debarge Véronique⁶,Jouannic Jean‐Marie⁷^ORCID,Massardier Jérôme⁸,Tsatsaris Vassilis⁹,Khoshnood Babak²,Lelong Nathalie², ,Delacourt Christophe¹⁰,Benachi Alexandra¹^ORCID

Affiliation:

1. Service de Gynécologie‐Obstétrique Hôpital Antoine Béclère AP‐HP Université Paris Saclay Clamart France

2. Université Paris Cité Centre of Research in Epidemiology and StatisticS (CRESS) Obstetrical Perinatal and Pediatric Epidemiology Research Team (EPOPé) INSERM INRA Paris France

3. Department of Obstetrics, Fetal Medicine and Surgery EA Fetus 7328 and LUMIERE Platform University of Paris Cité and Imagine Institute Necker‐Enfants Malades Hospital AP‐HP Paris France

4. Maternal Fetal Medicine Department Strasbourg University Hospital Inserm 1121 ‘Biomaterials and Bioengineering’ Strasbourg University Strasbourg France

5. Service de Gynécologie‐Obstétrique Centre Intercommunal de Créteil Créteil France

6. Université de Lille CHU Lille Lille France

7. Service de Médecine Fœtale Hôpital Armand Trousseau AP‐HP Sorbonne Université Paris France

8. Service de Gynécologie‐Obstétrique et Médecine Fœtale Hôpital Femme Mère Enfant Hospices Civils de Lyon Lyon France

9. Maternité Port‐Royal Hôpital Cochin AP‐HP FHU PREMA Université Paris Cité Paris France

10. Service de Pneumologie et Allergologie Pédiatrique Hôpital Necker‐Enfants Malades AP‐HP Paris France

Abstract

ABSTRACTObjectiveTo assess the frequency of fetal therapy for fetuses with congenital pulmonary malformations (CPMs) and to investigate their short‐term outcomes.MethodThe study population included 435 singleton fetuses diagnosed with CPMs from a national population‐based cohort study in France in 2015–2018. Information was obtained from medical records on CPM volume ratio (CVR), signs of compression, fetal therapy and perinatal outcomes. The characteristics and outcomes of fetuses with and without fetal therapy were compared using a univariate test.ResultsTwenty six fetuses (6.0%, 95% CI: 4.1–8.6) received at least one fetal therapy including thoracoamniotic shunts only (n = 3), antenatal steroids only (n = 12), and a combination of several therapies including thoracentesis and amniodrainage, in addition to shunts and steroids (n = 11). Compared with fetuses without fetal therapy, those who did have higher CVR (1.6 ± 0.3 vs. 0.7 ± 0.04, p < 0.001) and more severe signs of compression (73.1% vs. 12.8%, p < 0.001). The proportion of live births after fetal therapy was 84.6% versus 98.5% (p < 0.001) for those without fetal therapy and the hospital mortality rate was 13.6% versus 1.0% (p = 0.004), respectively.ConclusionA small minority of fetuses with CPMs underwent fetal therapy. These patients had a lower survival compared with those who did not receive fetal therapy.Trial RegistrationNCT02352207

Publisher

Wiley

Link

https://obgyn.onlinelibrary.wiley.com/doi/pdf/10.1002/pd.6646

Reference27 articles.

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2. Prenatal and Postnatal Management of Congenital Pulmonary Airway Malformation

3. Antenatal Management of Bronchopulmonary Sequestration by Intrafetal Vascular Laser Ablation under Ultrasound Control: Narrative Review of the Literature and Report of Three Cases