Unequivocal evidence supporting the segregated flow intestinal model that discriminates intestine versus liver first-pass removal with PBPK modeling-Reference-Cited by-同舟云学术

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Unequivocal evidence supporting the segregated flow intestinal model that discriminates intestine versus liver first-pass removal with PBPK modeling

Published:2017-03-28 Issue:3 Volume:38 Page:231-250
ISSN:0142-2782
Container-title:Biopharmaceutics & Drug Disposition
language:en
Short-container-title:Biopharm. Drug Dispos.

Author:

Pang K. Sandy¹,Yang Qi Joy¹,Noh Keumhan¹

Affiliation:

1. Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy; University of Toronto; Toronto, Ontario Canada

Publisher

Wiley

Subject

Pharmacology (medical),Pharmaceutical Science,Pharmacology,General Medicine

Reference110 articles.

1. Physiologically-based pharmacokinetic modeling for absorption, transport, metabolism and excretion;Pang;J Pharmacokinet Pharmacodyn,2010

2. Formed and preformed metabolites: facts and comparisons;Pang;J Pharm Pharmacol,2008

3. Identification of intestinal loss of a drug through physiologically based pharmacokinetic simulation of plasma concentration-time profiles;Peters;Clin Pharmacokinet,2008

4. Physiologically-based pharmacokinetic-pharmacodynamic modeling of 1α,25-dihydroxyvitamin D3 in mice;Ramakrishnan;Drug Metab Dispos,2016

5. Physiologically based pharmacokinetic (PBPK) modeling: it is here to stay!;Rostami-Hodjegan;Biopharm Drug Dispos,2012

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