Outcomes Associated with Reducing the Urine Alkalinization Threshold in Patients Receiving High-Dose Methotrexate

Author:

Drost Sarah A.1,Wentzell Jason R.12,Giguère Pierre12,McLurg Darcy L.1,Sabloff Mitchell23,Kanji Salmaan12,Nguyen Tiffany T.1

Affiliation:

1. Pharmacy Department; The Ottawa Hospital; Ottawa Ontario Canada

2. The Ottawa Hospital Research Institute; Ottawa Ontario Canada

3. Division of Hematology, Department of Medicine; University of Ottawa; Ottawa Ontario Canada

Publisher

Wiley

Subject

Pharmacology (medical)

Reference18 articles.

1. High dose methotrexate with leucovorin rescue: rationale and spectrum of antitumor activity;Frei;Am J Med,1980

2. Evaluation of incidence and risk factors for high-dose methotrexate-induced nephrotoxicity;Wiczer;J Oncol Pharm Pract,2015

3. Concepts in use of high-dose methotrexate therapy;Treon;Clin Chem,1996

4. Methotrexate. Cancer Care Ontario Formulary 2012 https://www.cancercare.on.ca/toolbox/drugformulary/

5. LaCasce AS Therapeutic use and toxicity of high-dose methotrexate. UpToDate 2014 http://www.uptodate.com/contents/therapeutic-use-and-toxicity-of-high-dose-methotrexate

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