Fatty acid synthase is a metabolic marker of cell proliferation rather than malignancy in ovarian cancer and its precursor cells

Author:

Veigel Daniel12,Wagner Renate12,Stübiger Gerald23,Wuczkowski Michael3,Filipits Martin24,Horvat Reinhard5,Benhamú Bellinda6,López-Rodríguez María Luz6,Leisser Asha17,Valent Peter278,Grusch Michael24,Hegardt Fausto G.91011,García Jordi101112,Serra Dolors91011,Auersperg Nelly13,Colomer Ramón1415,Grunt Thomas W.127

Affiliation:

1. Signaling Networks Program; Division of Oncology; Department of Medicine I; Medical University Vienna; Vienna Austria

2. Comprehensive Cancer Center, Medical University Vienna; Vienna Austria

3. Department of Vascular Biology and Thrombosis Research; Center of Physiology and Pharmacology, Medical University Vienna; Vienna Austria

4. Institute of Cancer Research; Department of Medicine I; Medical University of Vienna; Vienna Austria

5. Clinical Institute of Pathology; Medical University of Vienna; Vienna Austria

6. Departamento de Química Orgánica I; Facultad de Ciencias Químicas, Universidad Complutense de Madrid; Madrid Spain

7. Ludwig Boltzmann Cluster Oncology; Vienna Austria

8. Division of Hematology and Hemostaseology; Department of Medicine I; Medical University Vienna; Vienna Austria

9. Department of Biochemistry and Molecular Biology; Facultat de Farmàcia, Universitat de Barcelona; Barcelona Spain

10. Institut de Biomedicina de la Universitat de Barcelona (IBUB); Barcelona Spain

11. CIBERobn Fisiopatología de la Obesidad y la Nutrición; Instituto de Salud Carlos III; Madrid Spain

12. Department of Organic Chemistry; Facultat de Química; Universitat de Barcelona; Barcelona Spain

13. Department of Obstetrics and Gynecology; University of British Columbia; Vancouver BC Canada

14. Department of Medical Oncology; Hospital Universitario La Princesa; Madrid Spain

15. Clinical Research Program; Spanish National Cancer Research Center (CNIO); Madrid Spain

Funder

Spanish Ministry of Economy and Competitiveness

CIBER Fisiopatolog de la Obesidad y la Nutrición (CIBEROBN)

Instituto de Salud Carlos III

National Cancer Institute of Canada

Publisher

Wiley

Subject

Cancer Research,Oncology

Reference42 articles.

1. Major oncogenes and tumor suppressor genes involved in epithelial ovarian cancer (review);Aunoble;Int J Oncol,2000

2. Targeting signaling pathways in ovarian cancer;Reibenwein;Expert Opin Ther Targets,2008

3. Glutamine addiction: a new therapeutic target in cancer;Wise;Trends Biochem Sci,2010

4. Disrupting proton dynamics and energy metabolism for cancer therapy;Parks;Nat Rev Cancer,2013

5. New aspects of the Warburg effect in cancer cell biology;Bensinger;Semin Cell Dev Biol,2012

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