GPR30 knockdown weakens the capacity of CAF in promoting prostate cancer cell invasion via reducing macrophage infiltration and M2 polarization

Author:

Zhang Ran12ORCID,Zong Jiaojiao1,Peng Yanfei3,Shi Jiandang1,Du Xiaoling1,Liu Haitao4,Shen Yongmei1,Cao Jiasong1,Jia Bona5,Liu Feng6,Zhang Ju1

Affiliation:

1. Department of Biochemistry and Molecular Biology, College of Life Sciences, Bioactive Materials Key Lab of Ministry of Education Nankai University Tianjin China

2. Shandong Provincial Key Laboratory of Radiation Oncology, Cancer Research Center, Shandong Cancer Hospital and Institute Shandong First Medical University and Shandong Academy of Medical Sciences Jinan Shandong China

3. School of Integrative Medicine Tianjin University of Traditional Chinese Medicine Tianjin China

4. Shanghai First People's Hospital Shanghai Jiaotong University Shanghai China

5. Key Laboratory of Breast Cancer Prevention and Therapy (Ministry of Education), Tianjin Key Laboratory of Medical Epigenetics, Department of Biochemistry and Molecular Biology, Collaborative Innovation Center of Tianjin for Medical Epigenetics Tianjin Medical University Tianjin China

6. Key Laboratory of Infection and Immunity of Shandong Province and Department of Immunology, School of Biomedical Sciences Shandong University Jinan Shandong China

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference50 articles.

1. Cancer statistics, 2018

2. Alteration of the Antitumor Immune Response by Cancer-Associated Fibroblasts

3. Cancer-associated fibroblasts and macrophages

4. Reactive stroma as a predictor of biochemical‐free recurrence in prostate cancer;Ayala G;Clin Cancer Res,2003

5. Fibroblasts in cancer

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